Abstract:
:Almost all eukaryotic mRNAs acquire a poly(A) tail at the 3'-end by a concerted RNA processing event: cleavage and polyadenylation. The canonical PAP, PAPα, was considered the only nuclear PAP involved in general polyadenylation of mRNAs. A phosphoinositide-modulated nuclear PAP, Star-PAP, was then reported to regulate a select set of mRNAs in the cell. In addition, several non-canonical PAPs have been identified with diverse cellular functions. Further, canonical PAP itself exists in multiple isoforms thus illustrating the diversity of PAPs. In this review, we compare two nuclear PAPs, Star-PAP and PAPα with a general overview of PAP diversity in the cell. Emerging evidence suggests distinct niches of target pre-mRNAs for the two PAPs and that modulation of these PAPs regulates distinct cellular functions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Laishram RSdoi
10.1016/j.febslet.2014.05.029subject
Has Abstractpub_date
2014-06-27 00:00:00pages
2185-97issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00416-5journal_volume
588pub_type
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