Abstract:
:Perhydrohistrionicotoxin at micromolar concentrations blocked the nicotine-evoked transmitter release from perfused striatal (dopaminergic) and hippocampal (cholinergic) nerve terminals. Perhydrohistrionicotoxin failed to compete with [3H]nicotine for its high-affinity binding site in rat brain, suggesting that the action of this toxin on central nicotinic receptors is noncompetitive. From the dose-response curve, 50% inhibition of nicotine-evoked striatal dopamine release occurred at 5 microM perhydrohistrionicotoxin, a value similar to that obtained in frog sartorius muscle and Electrophorus electroplax. This close agreement may suggest that the ionic channel of the presynaptic nicotinic acetylcholine receptor of brain neurons has similar properties to those of the peripheral receptor.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rapier C,Wonnacott S,Lunt GG,Albuquerque EXdoi
10.1016/0014-5793(87)81363-7subject
Has Abstractpub_date
1987-02-23 00:00:00pages
292-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(87)81363-7journal_volume
212pub_type
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