Abstract:
:A human teratoma cell line (Tera 2) was grown in serum-free medium, and the population multiplication was stimulated by the addition of 1-10 ng basic fibroblast growth factor (bFGF)/ml. The bFGF-effect was abrogated by the addition of protamine sulphate. When high concentrations of bFGF were added, a preferential effect on cell locomotion was observed. 100 ng bFGF/ml stimulated cell movement but only exerted a marginal effect on cell multiplication. These observed exogenous requirements for multiplication and locomotion were complemented by the expression of bFGF receptors. Scatchard analysis of binding data suggests the existence of a high-affinity and a low-affinity class of receptors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Schofield PN,Granerus M,Lee A,Ektröm TJ,Engström Wdoi
10.1016/0014-5793(92)80044-hkeywords:
subject
Has Abstractpub_date
1992-02-24 00:00:00pages
154-8issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(92)80044-Hjournal_volume
298pub_type
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