Abstract:
:We have previously reported that synthetic dsRNA can activate p21 expression by targeting the p21 promoter, thereby suppressing the proliferation of human bladder cancer cells. As complementarity between dsRNA and its target sequences is necessary for RNA activation, miRNAs may also trigger p21 expression through the same mechanism. Here, the expression levels of three miRNAs (miR-370, miR-1180 and miR-1236) decreased in bladder cancer tissues compared to healthy controls and the levels of these mRNAs positively correlated with p21 mRNA levels. The three miRNAs induced nuclear p21 expression through p21-promoter binding. Overexpression of the three miRNAs inhibited the proliferation of bladder cancer cells mainly by regulating p21. Therefore, these miRNAs could be candidates for anti-cancer drugs.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wang C,Chen Z,Ge Q,Hu J,Li F,Hu J,Xu H,Ye Z,Li LCdoi
10.1016/j.febslet.2014.10.037subject
Has Abstractpub_date
2014-12-20 00:00:00pages
4654-64issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00786-8journal_volume
588pub_type
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