Abstract:
:We report the cDNA-deduced primary structure of the chicken counterpart of the murine dilute gene product, a member of the myosin I family. Comparison of the chicken and mouse sequences reveals a distinct pattern of domains of high and low sequence conservation. An internal deletion of 25 amino acids probably reflects differential mRNA processing. Compared with other myosin heavy chain molecules, sequence similarity is highest with the MYO2 gene product of Saccharomyces cerevisiae. The MYO2 protein, implicated in vectorial vesicle transport, is homologous to the dilute protein over practically its entire length. In addition, the C-terminal domain of the dilute protein is highly similar to a putative glutamic acid decarboxylase sequence cloned from mouse brain. Alternatively, this closely related clone might represent an isoform of the dilute protein derived from a second gene, potentially involved in genetic conditions related to dilute.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sanders G,Lichte B,Meyer HE,Kilimann MWdoi
10.1016/0014-5793(92)81123-4keywords:
subject
Has Abstractpub_date
1992-10-26 00:00:00pages
295-8issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(92)81123-4journal_volume
311pub_type
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