Abstract:
:In fibrous connective tissues, fibroblasts are organized into syncytia, cellular networks that enable matrix remodeling and that are interconnected by intercellular adherens junctions (AJs). The AJs of fibroblasts are mediated by N-cadherin, a broadly expressed classical cadherin that is critically involved in developmental processes, wound healing and several diseases of mesenchymal tissues. In contrast to E-cadherin-dependent junctions of epithelia, the formation of AJs in fibrous connective tissues is relatively uncharacterized. Work over the last several years has documented an expanding list of molecules which function to regulate N-cadherin mediated junctions such as: Fer, PTP1B, cortactin, calcium, gelsolin, PIP5KIgamma, PIP2, and the Rho family of GTPases. We present an overview on the regulation of N-cadherin-mediated junction formation that highlights recent molecular advances in the field and rationalizes the roles of N-cadherin in connective tissue function.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
El Sayegh TY,Kapus A,McCulloch CAdoi
10.1016/j.febslet.2006.12.029subject
Has Abstractpub_date
2007-01-23 00:00:00pages
167-74issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(06)01491-8journal_volume
581pub_type
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