Abstract:
:The accumulation of pre-PhoS under conditions of PhoS overproduction has been previously described. It is now demonstrated that during the induction of PhoS, a delay in the completion of polypeptide chain elongation can be detected. This delay is related to the extent of jamming of export sites by pre-PhoS or by other exported proteins. These results suggest that a component required for completion of pre-PhoS polypeptide becomes limiting, being titrated by the excess of nascent chains bearing signal peptides. This component thus probably acts at an early step in the export pathway.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Anba J,Lazdunski C,Pages JMdoi
10.1016/0014-5793(86)80204-6subject
Has Abstractpub_date
1986-02-03 00:00:00pages
9-13issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)80204-6journal_volume
196pub_type
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