Polyunsaturated fatty acids potentiate interleukin-1-stimulated arachidonic acid release by cells overexpressing type IIA secretory phospholipase A2.

Abstract:

:By analyzing human embryonic kidney 293 cell transfectants stably overexpressing various types of phospholipase A2 (PLA2), we have shown that polyunsaturated fatty acids (PUFAs) preferentially activate type IIA secretory PLA2 (sPLA2-IIA)-mediated arachidonic acid (AA) release from interleukin-1 (IL-1)-stimulated cells. When 293 cells prelabeled with 13H]AA were incubated with exogenous PUFAs in the presence of IL-1 and serum, there was a significant increase in [3H]AA release (in the order AA > linoleic acid > oleic acid), which was augmented markedly by sPLA2-IIA and modestly by type IV cytosolic PLA2 (cPLA2), but only minimally by type VI Ca2(+)-independent PLA2, overexpression. Transfection of cPLA2 into sPLA2-IIA-expressing cells produced a synergistic increase in IL-1-dependent [3H]AA release and subsequent prostaglandin production. Our results support the proposal that prior production of AA by cPLA2 in cytokine-stimulated cells destabilizes the cellular membranes, thereby rendering them more susceptible to subsequent hydrolysis by sPLA2-IIA.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Kambe T,Murakami M,Kudo I

doi

10.1016/s0014-5793(99)00702-4

keywords:

subject

Has Abstract

pub_date

1999-06-18 00:00:00

pages

81-4

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(99)00702-4

journal_volume

453

pub_type

杂志文章
  • Gibberellin biosynthesis in bacteria: separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum.

    abstract::Gibberellins are ent-kaurene-derived diterpenoid phytohormones produced by plants, fungi, and bacteria. The distinct gibberellin biosynthetic pathways in plants and fungi are known, but not that in bacteria. Plants typically use two diterpene synthases to form ent-kaurene, while fungi use only a single bifunctional di...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2008.12.052

    authors: Morrone D,Chambers J,Lowry L,Kim G,Anterola A,Bender K,Peters RJ

    更新日期:2009-01-22 00:00:00

  • Interaction between calmodulin and microtubule-associated proteins prepared at different stages of brain development.

    abstract::Rat brain microtubules were prepared at the adult stage and from immature (i.e., 4-day-old) animals. At an early stage of development, the composition of microtubule-associated proteins is qualitatively different from that found at the adult stage [(1982) Eur. J. Biochem. 129, 465-471]. The influence of calmodulin on ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(84)81148-5

    authors: Erneux C,Passareiro H,Nunez J

    更新日期:1984-07-09 00:00:00

  • Down-regulation of the protein kinase A pathway by activators of protein kinase C and intracellular Ca2+ in fibroblast cells.

    abstract::Many genes are regulated by the intracellular calcium, protein kinase C (PKC) and protein kinase A (PKA) pathways and it has been shown that these pathways synergize in some cell types, whereas they antagonize in others. Here we show that the calcium and PKC pathways suppress the effects mediated by the PKA pathway in...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(96)00748-x

    authors: Döbbeling U,Berchtold MW

    更新日期:1996-08-05 00:00:00

  • Deciphering the assembly pathway of Sm-class U snRNPs.

    abstract::The assembly of the Sm-class of uridine-rich small nuclear ribonucleoproteins (U snRNPs), albeit spontaneous in vitro, has recently been shown to be dependent on the aid of a large number of assisting factors in vivo. These factors are organized in two interacting units termed survival motor neuron (SMN)- and protein ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.febslet.2008.03.009

    authors: Neuenkirchen N,Chari A,Fischer U

    更新日期:2008-06-18 00:00:00

  • A structural tree for proteins containing S-like beta-sheets.

    abstract::A structural tree for proteins and domains containing S-like beta-sheets has been constructed. An S-like beta-sheet is taken as a starting structure in modelling or as a root structure of the tree. Larger structures are obtained by a stepwise addition of beta-strands and/or alpha-helices to the root S-like beta-sheet ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(98)01244-7

    authors: Efimov AV

    更新日期:1998-10-23 00:00:00

  • Cloning and expression of the hydrogenase gene from Clostridium butyricum in Escherichia coli.

    abstract::Hydrogenase gene from Clostridium butyricum was cloned in Escherichia coli HK16 (Hyd-) using pBR322 and PstI. The plasmid, pCBH1, containing hydrogenase gene was 7.3 MDa and pCBH1 had 5 PstI-DNA fragments (3.9, 2.6, 0.7, 0.03-0.04, less than 0.02 MDa, respectively). The hydrogenase activity of HK16 (pCBH1) was about 3...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(83)80689-9

    authors: Karube I,Urano N,Yamada T,Hirochika H,Sakaguchi K

    更新日期:1983-07-11 00:00:00

  • Transformation of rat fibroblasts by phospholipase C-gamma1 overexpression is accompanied by tyrosine dephosphorylation of paxillin.

    abstract::We previously have shown that the overexpression of phospholipase C-gamma1 (PLC-gamma1) in rat 3Y1 fibroblasts results in malignant transformation (Chang, J.-S., Noh, D.Y., Park, I.A., Kim, M;.J., Song, H., Ryu, S.H. and Suh, P.-G. (1997) Cancer Res. 57, 5465-5468). The transformed cells, which initially are in an elo...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(99)01338-1

    authors: Chang JS,Iwashita S,Lee YH,Kim MJ,Ryu SH,Suh PG

    更新日期:1999-10-22 00:00:00

  • Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV.

    abstract::In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. One hundred and seventy-four of these sites existed in two or more SARS-CoV genome sequences. According to the sequence polymorphism, all SARS-CoVs can be divided into three groups: (I...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2005.07.075

    authors: Wang ZG,Zheng ZH,Shang L,Li LJ,Cong LM,Feng MG,Luo Y,Cheng SY,Zhang YJ,Ru MG,Wang ZX,Bao QY

    更新日期:2005-09-12 00:00:00

  • Regulation of lipid synthesis in oil crops.

    abstract::Oil crops are in increasing demand both for food and as renewable sources of chemicals. It is therefore vital to understand how oil accumulation is regulated. Different ways of obtaining such information are discussed with an emphasis on metabolic control analysis. The usefulness of the latter has been well-illustrate...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.febslet.2013.05.018

    authors: Harwood JL,Guschina IA

    更新日期:2013-06-27 00:00:00

  • Clear cell carcinoma of the human ovary synthesizes and secretes a transferrin with microheterogeneity of lectin affinity.

    abstract::Human ovarian clear cell carcinoma cell line (transferrin (Tf)-non-producer), HAC 2, cells were adapted to grow in chemically defined synthetic medium when the cells were cultured with medium containing 10 micrograms/ml of insulin at least for 6 months. They synthesized and secreted constantly the 80 kDa protein immun...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(90)81225-d

    authors: Ohkawa K,Takada K,Takizawa N,Hatano T,Tsukada Y,Matsuda M

    更新日期:1990-09-17 00:00:00

  • Coexistence of two calsequestrin isoforms in rabbit slow-twitch skeletal muscle fibers.

    abstract::The cardiac and skeletal muscle isoforms of calsequestrin (CS), the low affinity, high capacity Ca2+ binding protein localized in the lumen of sarcoplasmic reticulum, are the products of two different genes (Fliegel, L., Leberer, E., Green, N.M. and MacLennan, D.H. (1982) FEBS Lett. 242, 297-300), and can be both puri...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(92)80241-8

    authors: Biral D,Volpe P,Damiani E,Margreth A

    更新日期:1992-03-09 00:00:00

  • Serum amyloid A and protein AA: molecular mechanisms of a transmissible amyloidosis.

    abstract::Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amoun...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.febslet.2009.04.026

    authors: Westermark GT,Westermark P

    更新日期:2009-08-20 00:00:00

  • Guanylate cyclase in rod outer segments of the toad retina. Effect of light and Ca2+.

    abstract::Guanylate cyclase activity was measured in disrupted rod outer segments of the toad retina. The experiments showed that cGMP is synthesized from GTP at a rate of 3 +/- 1 nmol/min per mg protein. In darkness this value is largely independent of the Ca2+ concentration, while it is enhanced by flashes of light of increas...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(86)81439-9

    authors: Pepe IM,Panfoli I,Cugnoli C

    更新日期:1986-07-14 00:00:00

  • Human release factor eRF1: structural organisation of the unique functional gene on chromosome 5 and of the three processed pseudogenes.

    abstract::In lower and higher eukaryotes, a family of tightly related proteins designated eRF1 (for eukaryotic release factor 1) catalyses termination of protein synthesis at all three stop codons. The human genome contains four eRF1 homologous sequences localised on chromosomes 5, 6, 7 and X. We report here the cloning and the...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(99)00795-4

    authors: Guenet L,Toutain B,Guilleret I,Chauvel B,Deaven LL,Longmire JL,Le Gall JY,David V,Le Treut A

    更新日期:1999-07-02 00:00:00

  • Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3.

    abstract::The inhibition of electron transport by unnatural (-)-antimycin A3 was examined with rat liver mitochondria and compared with that of natural (+)-antimycin A3. (-)-Antimycin A3 inhibited respiration about 1/100th as strongly as natural (+)-antimycin A3. (-)-Antimycin A3 binding to the cytochrome bc1 complex did not se...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(91)80834-p

    authors: Miyoshi H,Kondo H,Oritani T,Saitoh I,Iwamura H

    更新日期:1991-11-04 00:00:00

  • Translational regulations as specific traits of chloroplast gene expression.

    abstract::Studies of protein synthesis in the chloroplast compartment have revealed a unique combination of translational autoregulations and trans-regulations due to the delivery of a variety of nuclear factors that act post-transcriptionally. We show how these two characteristics concur to set the major step in the regulation...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0014-5793(02)03260-x

    authors: Choquet Y,Wollman FA

    更新日期:2002-10-02 00:00:00

  • Oral secretions from herbivorous lepidopteran larvae exhibit ion channel-forming activities.

    abstract::Feeding insects introduce oral secretions (OS) into the wounded tissue of the attacked plant. Various OS-derived molecules must be involved in subsequent processes including the induction of plant defence reactions. Using the planar lipid bilayer membrane technique, isolated OS were analyzed with respect to their memb...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2007.01.067

    authors: Maischak H,Grigoriev PA,Vogel H,Boland W,Mithöfer A

    更新日期:2007-03-06 00:00:00

  • Solubilization and partial purification of protein kinase systems from brain membranes that phosphorylate calspectin. A spectrin-like calmodulin-binding protein (fodrin).

    abstract::In brain tissue a spectrin-like calmodulin-binding protein calspectin, or fodrin, is concentrated in a synaptosome fraction, where most of the calspectin is associated with the synaptic membranes. This endogenous calspectin was phosphorylated by protein kinase system(s) associated with the membranes. Here, we report t...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(82)81331-8

    authors: Sobue K,Kanda K,Kakiuchi S

    更新日期:1982-12-13 00:00:00

  • The chlorophyll-binding protein IsiA is inducible by high light and protects the cyanobacterium Synechocystis PCC6803 from photooxidative stress.

    abstract::The products of the isiAB operon are a chlorophyll antenna protein (IsiA) and flavodoxin (IsiB), which accumulate in cyanobacteria grown under iron starvation conditions. Here we show that strong light triggers de-repression of isiAB transcription and leads to IsiA and flavodoxin accumulation under iron replete condit...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2005.03.021

    authors: Havaux M,Guedeney G,Hagemann M,Yeremenko N,Matthijs HC,Jeanjean R

    更新日期:2005-04-25 00:00:00

  • Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes.

    abstract::Increases in choline containing metabolites have been associated with a number of disorders, including malignant cell growth. In this study, high resolution magic angle spinning (1)H nuclear magnetic resonance spectroscopy was employed to monitor metabolite changes during cell transfection, and an increase in phosphoc...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(01)03175-1

    authors: Griffin JL,Mann CJ,Scott J,Shoulders CC,Nicholson JK

    更新日期:2001-12-07 00:00:00

  • The enzymatic activity of phosphoglucose isomerase is not required for its cytokine function.

    abstract::PGI is a housekeeping gene encoding phosphoglucose isomerase (PGI) a glycolytic enzyme that also functions as a cytokine (autocrine motility factor (AMF)/neuroleukin/maturation factor) upon secretion from the cell and binding to its 78 kDa seven-transmembrane domain receptor (gp78/AMF-R). PGI contains a CXXC motif, ch...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-6793(02)03773-0

    authors: Tsutsumi S,Gupta SK,Hogan V,Tanaka N,Nakamura KT,Nabi IR,Raz A

    更新日期:2003-01-16 00:00:00

  • Bicarbonate ions and pH regulation of Leishmania major promastigotes.

    abstract::Leishmania major promastigotes are parasites endowed with a plasma membrane electrogenic H+ pump and anionic channels. These systems have been thought to contribute to pH homeostasis of parasites and environmental adaptation by mediating extrusion of protons which are either generated metabolically or result from exog...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)00171-5

    authors: Vieira L,Cabantchik ZI

    更新日期:1995-03-13 00:00:00

  • Dissection of the dual function of the beta-subunit of protein kinase CK2 ('casein kinase-2'): a synthetic peptide reproducing the carboxyl-terminal domain mimicks the positive but not the negative effects of the whole protein.

    abstract::The dual function of the regulatory beta-subunit of protein kinase CK2 is highlighted by its ability to abolish calmodulin phosphorylation in contrast to its stimulatory effect on the phosphorylation of peptide substrates. Here we show that a synthetic peptide reproducing the C-terminal region of the beta-subunit (bet...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/0014-5793(95)00295-k

    authors: Marin O,Meggio F,Boldyreff B,Issinger OG,Pinna LA

    更新日期:1995-04-17 00:00:00

  • Astrocytes enhance radical defence in capillary endothelial cells constituting the blood-brain barrier.

    abstract::Astrocytes (AC) induce blood-brain barrier (BBB) properties in brain endothelial cells (EC). As antioxidative activity (AOA) is assumed to be a BBB characteristic, we tested whether AC improve AOA of EC. Monocultivated AC showed higher AOA [manganese superoxide dismutase (SOD), catalase (Cat), glutathione peroxidase (...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(99)00451-2

    authors: Schroeter ML,Mertsch K,Giese H,Müller S,Sporbert A,Hickel B,Blasig IE

    更新日期:1999-04-23 00:00:00

  • Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.

    abstract::Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses. Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis. We postulate that the ra...

    journal_title:FEBS letters

    pub_type: 信件

    doi:10.1002/1873-3468.12941

    authors: Mikulecky P,Andreeva E,Amara P,Weissenhorn W,Nicolet Y,Macheboeuf P

    更新日期:2018-01-01 00:00:00

  • Valine substituted winter flounder 'antifreeze': preservation of ice growth hysteresis.

    abstract::Three mutant polypeptides of the type I 37-residue winter flounder 'antifreeze' protein have been synthesized. All four threonine residues in the native peptide were been mutated to serine, valine and glycine respectively and two additional salt bridges were incorporated into the sequences in order to improve aqueous ...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(98)00652-8

    authors: Haymet AD,Ward LG,Harding MM,Knight CA

    更新日期:1998-07-03 00:00:00

  • Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.

    abstract::The enzyme telomerase is necessary for the synthesis and maintenance of telomere length. The catalytic subunit, telomerase reverse transcriptase (TERT), is regulated by interaction with the 90 kDa heat shock protein (HSP90) and by Akt-dependent phosphorylation. Here, we demonstrate that HSP90 and Akt physically intera...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(03)00058-9

    authors: Haendeler J,Hoffmann J,Rahman S,Zeiher AM,Dimmeler S

    更新日期:2003-02-11 00:00:00

  • Analysis of the black-eyed pea trypsin and chymotrypsin inhibitor-alpha-chymotrypsin complex.

    abstract::The black-eyed pea trypsin and chymotrypsin inhibitor (BTCI) is a member of the Bowman-Birk protease inhibitor (BBI) family. The three-dimensional model of the BTCI-chymotrypsin complex was built based on the homology to Bowman-Birk inhibitors with known structures. An extensive theoretical and experimental study of t...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/s0014-5793(97)00419-5

    authors: de Freitas SM,de Mello LV,da Silva MC,Vriend G,Neshich G,Ventura MM

    更新日期:1997-06-09 00:00:00

  • Kinetic and thermodynamic properties of two barley thioredoxin h isozymes, HvTrxh1 and HvTrxh2.

    abstract::Barley thioredoxin h isozymes 1 (HvTrxh1) and barley thioredoxin h isozymes 2 (HvTrxh2) show distinct spatiotemporal distribution in germinating seeds. Using a novel approach involving measurement of bidirectional electron transfer rates between Escherichia coli thioredoxin, which exhibits redox-dependent fluorescence...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2010.06.028

    authors: Maeda K,Hägglund P,Björnberg O,Winther JR,Svensson B

    更新日期:2010-08-04 00:00:00

  • Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats.

    abstract::Recent evidence indicates that cell-cycle regulating proteins are involved in apoptotic process in post-mitotic neurons. In this study, we examined cell-cycle regulators for G1/S cell-cycle progression after a transient focal cerebral ischemia induced by middle cerebral artery (MCA) occlusion. In the cerebral frontopa...

    journal_title:FEBS letters

    pub_type: 杂志文章

    doi:10.1016/j.febslet.2005.07.028

    authors: Wen Y,Yang S,Liu R,Simpkins JW

    更新日期:2005-08-29 00:00:00