Abstract:
:Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short-term experiments, insulin-like growth factor I (IGF I) stimulated the incorporation of [14C] glucose into glycogen. When IGF I was present in the medium during 6 days the cell number increased slightly and there was a substantial, disproportionate rise in alkaline phosphatase activity of the cultures. Thus, IGF I stimulates growth, and in addition, and in contrast to other growth factors, mainly enhances differentiation of osteoblasts.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Schmid C,Steiner T,Froesch ERdoi
10.1016/0014-5793(84)81015-7subject
Has Abstractpub_date
1984-07-23 00:00:00pages
48-52issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(84)81015-7journal_volume
173pub_type
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