Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells.

Abstract:

:Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short-term experiments, insulin-like growth factor I (IGF I) stimulated the incorporation of [14C] glucose into glycogen. When IGF I was present in the medium during 6 days the cell number increased slightly and there was a substantial, disproportionate rise in alkaline phosphatase activity of the cultures. Thus, IGF I stimulates growth, and in addition, and in contrast to other growth factors, mainly enhances differentiation of osteoblasts.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Schmid C,Steiner T,Froesch ER

doi

10.1016/0014-5793(84)81015-7

subject

Has Abstract

pub_date

1984-07-23 00:00:00

pages

48-52

issue

1

eissn

0014-5793

issn

1873-3468

pii

0014-5793(84)81015-7

journal_volume

173

pub_type

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