Abstract:
:We report that the mitotic inhibitor, vinblastine (VLB), is highly toxic to the malarial parasite, Plasmodium falciparum. In cultures in vitro growth is inhibited by 50% at a VLB level of about 28 nM, and totally abolished at a level of 100 nM. By tests on synchronized cultures we have found that the effect of VLB takes place at the trophozoite stage. Colcemid also inhibits schizogony with somewhat different kinetics. By mutagenesis with nitrosoguanidine followed by VLB selection we have isolated a VLB-resistant mutant which exhibits cross-resistance to vincristine. These data suggest a critical role of microtubules in the asexual schizogonic cycle of P. falciparum.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Usanga EA,O'Brien E,Luzzato Ldoi
10.1016/0014-5793(86)81077-8subject
Has Abstractpub_date
1986-12-01 00:00:00pages
23-7issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)81077-8journal_volume
209pub_type
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