Abstract:
:Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial carriers. Here, we highlight recent findings regarding UCP2 function in the immune system. UCP2 controls immune cell activation by modulating MAPK pathways and the production of mitochondrial reactive oxygen species. In several models of infection, inflammation and autoimmunity, a regulatory impact of UCP2 was demonstrated by its direct implication in the production of cytokines and nitric oxide and in cell migration. In addition, UCP2 is reported as a key protein for oxidation of fatty acids, glutamine and glucose. Therefore we present a model of how the regulation of nutrient oxidation by UCP2 promotes immune cell activation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Emre Y,Nübel Tdoi
10.1016/j.febslet.2010.03.014subject
Has Abstractpub_date
2010-04-16 00:00:00pages
1437-42issue
8eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00208-5journal_volume
584pub_type
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