Uncoupling protein UCP2: when mitochondrial activity meets immunity.

Abstract:

:Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial carriers. Here, we highlight recent findings regarding UCP2 function in the immune system. UCP2 controls immune cell activation by modulating MAPK pathways and the production of mitochondrial reactive oxygen species. In several models of infection, inflammation and autoimmunity, a regulatory impact of UCP2 was demonstrated by its direct implication in the production of cytokines and nitric oxide and in cell migration. In addition, UCP2 is reported as a key protein for oxidation of fatty acids, glutamine and glucose. Therefore we present a model of how the regulation of nutrient oxidation by UCP2 promotes immune cell activation.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Emre Y,Nübel T

doi

10.1016/j.febslet.2010.03.014

subject

Has Abstract

pub_date

2010-04-16 00:00:00

pages

1437-42

issue

8

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(10)00208-5

journal_volume

584

pub_type

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