Abstract:
:Domain structures of porcine lung and testicular angiotensin-converting enzymes (ACE) were studied by radiation inactivation to test the hypothesis that lung ACE has two catalytic sites localized to discrete, structurally independent domains (the N- and C-domains) of approximately equal size. The minimum functional sizes of lung and testicular ACE, calculated from the inactivation curves obtained, were 140 and 74 kDa, respectively. Since testicular ACE has been demonstrated to contain only the C domain, this result indicates that the two domains in lung ACE are not independent but are, in fact, structurally tightly linked.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sakaguchi H,Hirose S,Kume T,Hagiwara Hdoi
10.1016/0014-5793(92)80882-hkeywords:
subject
Has Abstractpub_date
1992-06-29 00:00:00pages
144-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(92)80882-Hjournal_volume
305pub_type
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