Abstract:
:Prokaryotic aminoacylated-transfer RNAs often need to be efficiently segregated between translation and other cellular biosynthetic pathways. Many clinically relevant bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa direct some aminoacylated-tRNA species into peptidoglycan biosynthesis and/or membrane phospholipid modification. Subsequent indirect peptidoglycan cross-linkage or change in membrane permeability is often a prerequisite for high-level antibiotic resistance. In Streptomycetes, aminoacylated-tRNA species are used for antibiotic synthesis as well as antibiotic resistance. The direction of coding aminoacylated-tRNA molecules away from translation and into antibiotic resistance and synthesis pathways are discussed in this review.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Shepherd J,Ibba Mdoi
10.1016/j.febslet.2013.07.036subject
Has Abstractpub_date
2013-09-17 00:00:00pages
2895-904issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00565-6journal_volume
587pub_type
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