The nuclear-encoded 18 kDa (IP) AQDQ subunit of bovine heart complex I is phosphorylated by the mitochondrial cAMP-dependent protein kinase.


:In bovine heart mitochondria a protein of M(r) 18 kDa, phosphorylated by mtPKA, is associated to the NADH-ubiquinone oxidoreductase in the inner membrane and is present in purified preparation of this complex. The 18 kDa phosphoprotein has now been isolated and sequenced. It is identified as the 18 kDa (IP) AQDQ subunit of complex I, a protein of 133 amino acids with a phosphorylation consensus site RVS at position 129-131.




FEBS letters


Papa S,Sardanelli AM,Cocco T,Speranza F,Scacco SC,Technikova-Dobrova Z




Has Abstract


1996-02-05 00:00:00














  • Stability engineering of the human antibody repertoire.

    abstract::Human monoclonal antibodies often display limited thermodynamic and colloidal stabilities. This behavior hinders their production, and places limitations on the development of novel formulation conditions and therapeutic applications. Antibodies are highly diverse molecules, with much of the sequence variation observe...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Rouet R,Lowe D,Christ D

    更新日期:2014-01-21 00:00:00

  • Characterization of a new membrane-bound cytochrome c of Rhodopseudomonas capsulata.

    abstract::A cytochrome c (cyt. c) was solubilized with Triton-X-100 and co-purified with cytochrome c oxidase from membranes of chemotrophically grown cells of Rhodopseudomonas capsulata. Cyt. c and cytochrome oxidase were separated on Sephadex G-50 columns. Antibodies against cytochrome c2 from the same bacterium did not cross...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hüdig H,Drews G

    更新日期:1983-02-21 00:00:00

  • The three-dimensional solution structure of a constrained peptidomimetic in water and in chloroform. Observation of solvent induced hydrophobic cluster.

    abstract::A large number of protein-protein interactions involved turn or loop regions. The excised linear peptides from these regions reveal complex conformational averaging. To circumvent this motional averaging and to stabilize the beta-turn conformation, extensive effort has been devoted to the design of constrained peptido...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Lee MS,Gardner B,Kahn M,Nakanishi H

    更新日期:1995-02-13 00:00:00

  • Role of prostaglandin E2 in peptidoglycan mediated iNOS expression in mouse peritoneal macrophages in vitro.

    abstract::Many extracellular stimuli, e.g. microbial products, cytokines etc., result in the expression of inducible nitric oxide synthase (iNOS) in macrophages. However, it is not known whether expression of the iNOS gene in response to microbial products is a primary response of macrophages, or is the result of paracrine/auto...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dahiya Y,Pandey RK,Bhatt KH,Sodhi A

    更新日期:2010-10-08 00:00:00

  • Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin.

    abstract::Trypsin immobilized on collagen membranes has been used to digest accessible ribosomal proteins of rat liver 40 S subunits. Six proteins (S2, S6, S10, S14, S15 and S25) have been found to be highly exposed on the surface of 40 S particles. They appear to be in close physical contact and localized in the same region of...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Marion MJ,Marion C

    更新日期:1988-05-23 00:00:00

  • Cell type-specific processing of human Tau proteins in Drosophila.

    abstract::Accumulation of hyperphosphorylated Tau is associated with a number of neurodegenerative diseases collectively known as tauopathies. Differences in clinical and cognitive profiles among them suggest differential sensitivity of neuronal populations to Tau levels, phosphorylation and mutations. We used tissue specific e...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Grammenoudi S,Kosmidis S,Skoulakis EM

    更新日期:2006-08-21 00:00:00

  • LVV- and VV-hemorphins: comparative levels in rat tissues.

    abstract::Screening of hemorphins in extracts of rat lung, brain, heart and spleen was carried out. The threshold for detection of hemorphins was 0.01 nmol for spleen and 0.05 nmol for other tissues. Both the content and the composition of hemorphins differed significantly in the tissues analyzed. Heart and lung extracts were r...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yatskin ON,Philippova MM,Blishchenko EYu,Karelin AA,Ivanov VT

    更新日期:1998-05-29 00:00:00

  • Mitochondrial thioredoxin in regulation of oxidant-induced cell death.

    abstract::Mitochondrial thioredoxin (mtTrx) can be oxidized in response to inducers of oxidative stress; yet the functional consequences of the oxidation have not been determined. This study evaluated the redox status of mtTrx and its association to oxidant-induced apoptosis. Results showed that mtTrx was oxidized after exposur...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chen Y,Cai J,Jones DP

    更新日期:2006-12-11 00:00:00

  • Backbone folding of the polypeptide cardiac stimulant anthopleurin-A determined by nuclear magnetic resonance, distance geometry and molecular dynamics.

    abstract::The solution conformation of the cardiac stimulatory sea anemone polypeptide anthopleurin-A has been characterised using distance geometry and restrained molecular dynamics calculations. A set of 253 approximate interproton distance restraints and 14 peptide backbone torsion angle restraints derived from two-dimension...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Torda AE,Mabbutt BC,van Gunsteren WF,Norton RS

    更新日期:1988-11-07 00:00:00

  • Cloning and functional characterisation of the mouse P2X7 receptor.

    abstract::We have isolated a 1785-bp complementary DNA (cDNA) encoding the murine P2X7 receptor subunit from NTW8 mouse microglial cells. The encoded protein has 80%, and 85% homology to the human and rat P2X7 subunits, respectively. Functional properties of the heterologously expressed murine P2X7 homomeric receptor broadly re...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chessell IP,Simon J,Hibell AD,Michel AD,Barnard EA,Humphrey PP

    更新日期:1998-11-13 00:00:00

  • Determination and cellular localization of adenylyl cyclase isozymes expressed in embryonic chick heart.

    abstract::Mammalian heart has been reported to express AC isozymes (types V and VI) that are inhibited by < microM [Ca2+]; avian heart has been reported to express adenylyl cyclase activity that is inhibited by < microM [Ca2]. We have used reverse transcription polymerase chain reaction (RT-PCR) to determine that type V and VI ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yu HJ,Unnerstall JR,Green RD

    更新日期:1995-10-23 00:00:00

  • Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins.

    abstract::The assembly of iron-sulfur (Fe/S) clusters in a living cell is mediated by a complex machinery which, in eukaryotes, is localised within mitochondria. Here, we report on a new component of this machinery, the protein Isa2p of the yeast Saccharomyces cerevisiae. The protein shares sequence similarity with yeast Isa1p ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Pelzer W,Mühlenhoff U,Diekert K,Siegmund K,Kispal G,Lill R

    更新日期:2000-07-07 00:00:00

  • Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells.

    abstract::The amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases to release amyloid-β peptide (Aβ), the main component found in senile plaques of Alzheimer's disease (AD) patient brains. Alternatively, APP can be cleaved within the Aβ sequence by α-secretase, thus precluding the generation of Aβ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: León-Otegui M,Gómez-Villafuertes R,Díaz-Hernández JI,Díaz-Hernández M,Miras-Portugal MT,Gualix J

    更新日期:2011-07-21 00:00:00

  • Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580.

    abstract::SB203580 (4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imi dazole) is widely used as a specific inhibitor of p38 mitogen-activated protein kinase (MAPK). Here, we report that SB203580 activates the serine/threonine kinase Raf-1 in quiescent smooth muscle cells in a dose-dependent fashion. The concentr...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kalmes A,Deou J,Clowes AW,Daum G

    更新日期:1999-02-05 00:00:00

  • Hirudin or hirudin-like factor - that is the question: insights from the analyses of natural and synthetic HLF variants.

    abstract::The hirudin-like factor 1 (HLF1) of Hirudo medicinalis belongs to a new class of leech-derived factors. In previous investigations, HLF1 did not exhibit anticoagulatory activities. Here, we describe the analysis of natural and synthetic variants of HLF1 and HLF-Hyb, a yet uncharacterized member of the HLF family. Modi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Müller C,Lukas P,Böhmert M,Hildebrandt JP

    更新日期:2020-03-01 00:00:00

  • Saccharomyces cerevisiae mRNA populations of different intrinsic stability in unstressed and heat shocked cells display almost constant m7GpppA:m7GpppG 5'-cap structure ratios.

    abstract::The half-lives of mRNAs in yeast vary from about 1 to over 100 min. While mRNA stabilities must strongly influence overall gene expression in this organism, very little is known about how they are determined. Labellings of yeast cells were conducted to investigate whether the 5'-cap structures of yeast mRNAs might inf...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Piper PW,Curran B,Davies W,Hirst K,Seward K

    更新日期:1987-08-10 00:00:00

  • Role of molecular chaperones in inclusion body formation.

    abstract::Protein misfolding and aggregation are linked to several degenerative diseases and are responsible for the formation of bacterial inclusion bodies. Roles of molecular chaperones in promoting protein deposition have been speculated but not proven in vivo. We have investigated the involvement of individual chaperones in...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Carrió MM,Villaverde A

    更新日期:2003-02-27 00:00:00

  • Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3, a snake venom hemorrhagic metalloproteinase.

    abstract::The functionality of the disintegrin-like/cysteine-rich domains of snake venom metalloproteinases (SVMPs) has been shown to reside in the cysteine-rich region, which can interact with VWA-containing proteins. Recently, the hyper-variable region (HVR) of the cysteine-rich domain was suggested to constitute a potential ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Menezes MC,Paes Leme AF,Melo RL,Silva CA,Della Casa M,Bruni FM,Lima C,Lopes-Ferreira M,Camargo AC,Fox JW,Serrano SM

    更新日期:2008-11-26 00:00:00

  • Gly166 in the NK1 receptor regulates tachykinin selectivity and receptor conformation.

    abstract::We have studied the pharmacological properties of genetically engineered human NK1 tachykinin receptors in which residues at the extracellular surface of the fourth transmembranal domain were substituted with the corresponding amino acids from the NK2 receptor. We show that substitution of G166C:Y167F in the human NK1...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ciucci A,Palma C,Riitano D,Manzini S,Werge TM

    更新日期:1997-10-27 00:00:00

  • The integrin alphaVbeta6 binds and activates latent TGFbeta3.

    abstract::Transforming growth factors-beta (TGFbeta1, 2 and 3) are secreted in a complex with their propeptides (latency-associated peptide 1 (LAP1), 2 and 3). TGFbeta signaling requires the dissociation of LAP and TGFbeta, a process termed latent TGFbeta activation. This process is a critical but incompletely understood step i...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Annes JP,Rifkin DB,Munger JS

    更新日期:2002-01-30 00:00:00

  • Useful 1O2 (1delta g) generator, 3-(4'-methyl-1'-naphthyl)-propionic acid, 1',4'-endoperoxide (NEPO), for dioxygenation of squalence (a skin surface lipid) in an organic solvent and bacterial killing in aqueous medium.

    abstract::3-(4'-Methyl-1'-naphthyl)-propionic acid, 1',4'-endoperoxide (NEPO) provides singlet state of oxygen (1O2, 1delta g) at 37 degrees C in sodium phosphate buffer (pH 7.2), acetate buffer (pH 4.5), methanol or chloroform, through the retro-Diels-Alder reaction. The total amount of 1O2 generated by NEPO was calculated usi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nakano M,Kambayashi Y,Tatsuzawa H,Komiyama T,Fujimori K

    更新日期:1998-07-31 00:00:00

  • Electrogenicity of the lysosomal proton pump.

    abstract::Using acridine orange as a pH gradient probe, the effects of valinomycin and FCCP on the pH gradient across lysosomal membranes in an ATP-free medium as well as on the rate of the inward ATP-driven proton translocation were investigated. Both lysosome-enriched and highly purified lysosomal preparations from rat liver ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dell'Antone P

    更新日期:1984-03-12 00:00:00

  • Regulation of bioactive beta-endorphin processing in rat pars intermedia.

    abstract::Acid extracts of rat pituitary neuro-intermediate lobes have been shown by ion-exchange chromatography and radio-immunoassay to contain predominantly the inactive derivatives of beta-endorphin, alpha, N-acetyl beta-endorphin 1-27 and alpha, N-acetyl beta-endorphin 1-26; the biologically active form, beta-endorphin 1-3...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ham J,Smyth DG

    更新日期:1984-10-01 00:00:00

  • Protein transport via the cpTat pathway displays cooperativity and is stimulated by transport-incompetent substrate.

    abstract::Kinetic analyses of cpTat-mediated protein transport across the thylakoid membrane were conducted, revealing three important characteristics of this translocation pathway. First, transport via the cpTAT system displays a non-Michaelis-Menten, sigmoidal rate-substrate relationship with an apparent Hill coefficient of 1...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Alder NN,Theg SM

    更新日期:2003-04-10 00:00:00

  • Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis.

    abstract::As the initiator of DNA double-strand breaks during meiosis in Saccharomyces cerevisiae, the SPO11 protein is essential for recombination. Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialization of a DNA cleavage function for meiotic recombination. To determine whether this ex...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Shannon M,Richardson L,Christian A,Handel MA,Thelen MP

    更新日期:1999-12-03 00:00:00

  • ATM blocks tunicamycin-induced endoplasmic reticulum stress.

    abstract::Endoplasmic reticulum stress (ER-stress) is associated with ataxia telangiectasia mutated (ATM) gene. We present here conclusive data showing that ATM blocks ER-stress induced by tunicamycin or ionizing radiation (IR). X-box protein-1 (XBP-1) splicing, GRP78 expression and caspase-12 activation were increased by tunic...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: He L,Kim SO,Kwon O,Jeong SJ,Kim MS,Lee HG,Osada H,Jung M,Ahn JS,Kim BY

    更新日期:2009-03-04 00:00:00

  • ATP-dependent degradation of SulA, a cell division inhibitor, by the HslVU protease in Escherichia coli.

    abstract::HslVU is an ATP-dependent protease consisting of two multimeric components, the HslU ATPase and the HslV peptidase. To gain an insight into the role of HslVU in regulation of cell division, the reconstituted enzyme was incubated with SulA, an inhibitor of cell division in Escherichia coli, or its fusion protein with m...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Seong IS,Oh JY,Yoo SJ,Seol JH,Chung CH

    更新日期:1999-07-30 00:00:00

  • Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits.

    abstract::The acronym CK2 denotes a highly pleiotropic Ser/Thr protein kinase whose over-expression correlates with neoplastic growth. A vexed question about the enigmatic regulation of CK2 concerns the actual existence in living cells of the catalytic (alpha and/or alpha') and regulatory beta-subunits of CK2 not assembled into...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Salvi M,Sarno S,Marin O,Meggio F,Itarte E,Pinna LA

    更新日期:2006-07-10 00:00:00

  • Molecular mechanism of molt-inhibiting hormone (MIH) induced suppression of ecdysteroidogenesis in the Y-organ of mud crab: Scylla serrata.

    abstract::The present study was focused on the regulation of ecdysteroidogenesis in the Y-organ of Scylla serrata during molting cycle. A strong expression of molt-inhibiting hormone (MIH) and phosphorylation of ERK was predominantly observed in the postmolt and intermolt stages of Y-organs, whereas protein kinase C, steroidoge...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Imayavaramban L,Dhayaparan D,Devaraj H

    更新日期:2007-11-13 00:00:00

  • Intracellular distribution of DNA methyltransferase during the cell cycle.

    abstract::The intracellular distribution of DNA methyltransferase has been analyzed in synchronously proliferating human cells. The localization of DNA methyltransferase was determined immunocytochemically using monoclonal antibodies directed against this enzyme. DNA methyltransferase was found to accumulate predominantly in nu...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Vogel MC,Papadopoulos T,Müller-Hermelink HK,Drahovsky D,Pfeifer GP

    更新日期:1988-08-15 00:00:00