Abstract:
:We examined the expression of peroxisome proliferator-activated receptors (PPARs) and the role of PPARs in cytokine production in mouse bone marrow-derived mast cells (mBMMCs). mBMMCs expressed PPARbeta strongly and gamma slightly, but not alpha. Activation of mBMMCs with antigen or calcium ionophore resulted in the increased expression of PPARgamma mRNA specifically. 15-Deoxy-Delta(12, 14)-prostaglandin J(2) (15d-PGJ(2)) and troglitazone, all PPARgamma ligands, attenuated the antigen-induced cytokine production by mBMMCs. Carbaprostacyclin, a PPARbeta ligand, also inhibited cytokine production, whereas PPARalpha ligands did not. These results suggest that PPARbeta and gamma might be included in the negative regulation of mast cell activation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sugiyama H,Nonaka T,Kishimoto T,Komoriya K,Tsuji K,Nakahata Tdoi
10.1016/s0014-5793(00)01169-8keywords:
subject
Has Abstractpub_date
2000-02-11 00:00:00pages
259-62issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)01169-8journal_volume
467pub_type
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