Abstract:
:The chemotherapeutic activity of three synthetic antibacterial peptides was investigated. KLKLLLLLKLK-NH2 and its D-enantiomer showed significant chemotherapeutic activity in MRSA-infected mice, whereas KLKLLLKLK-NH2, which showed the highest antibacterial activity among them in vitro, was found to have almost no ability to prevent MRSA infection. These results suggest that the antibacterial activity of peptides assessed in vitro does not necessarily correlate with their chemotherapeutic activity. We found that KLKLLLLLKLK-NH2 and its D-enantiomer, but not KLKLLLKLK-NH2, have the ability to activate human neutrophils to produce superoxide, suggesting that the prevention of MRSA infection by these peptides is not simply due to their direct bactericidal activity but to augmentation of the systemic defense mechanism mediated by neutrophils.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nakajima Y,Alvarez-Bravo J,Cho J,Homma K,Kanegasaki S,Natori Sdoi
10.1016/s0014-5793(97)01101-0subject
Has Abstractpub_date
1997-09-22 00:00:00pages
64-6issue
1eissn
0014-5793issn
1873-3468pii
S0014579397011010journal_volume
415pub_type
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