Abstract:
:Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial bilayers in a process favoured by oxidising conditions and low pH. They are structurally plastic, with CLIC1 adopting two distinct soluble conformations. Phylogenetic and structural data indicate that CLICs are likely to have enzymatic function. The physiological role of CLICs appears to be maintenance of intracellular membranes, which is associated with tubulogenesis but may involve other substructures.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Littler DR,Harrop SJ,Goodchild SC,Phang JM,Mynott AV,Jiang L,Valenzuela SM,Mazzanti M,Brown LJ,Breit SN,Curmi PMdoi
10.1016/j.febslet.2010.01.027subject
Has Abstractpub_date
2010-05-17 00:00:00pages
2093-101issue
10eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00050-5journal_volume
584pub_type
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