Abstract:
:Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (I10) to suppress E10 splicing, which was located just after the stem-loop region previously proposed in human sequence and found to potentially form another stem-loop. Human I10 with a mutation (+29G to A) causing a decreased E10 splicing was also predicted to form similar double stem-loop, suggesting that this element is universally involved in regulation of E10 splicing.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yamashita T,Tomiyama T,Li Q,Numata H,Mori Hdoi
10.1016/j.febslet.2004.11.090keywords:
subject
Has Abstractpub_date
2005-01-03 00:00:00pages
241-4issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(04)01477-2journal_volume
579pub_type
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