Abstract:
:The expression of rat brain voltage-sensitive Na+ channel mRNAs in Schwann cells was examined using in situ hybridization cytochemistry and RT-PCR. The mRNAs of rat brain Na+ channel subtype II and III, but not subtype I, were detected in cultured Schwann cells from sciatic nerve and in intact sciatic nerve, which contains Schwann cells but not neuronal cell bodies. These results indicate that rat brain Na+ channel mRNAs, which have been considered as mainly neuronal-type messages, are also expressed in glial cells in vitro and in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Oh Y,Black JA,Waxman SGdoi
10.1016/0014-5793(94)00807-8subject
Has Abstractpub_date
1994-08-22 00:00:00pages
342-6issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(94)00807-8journal_volume
350pub_type
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