Abstract:
:In endocrine cells the regulated secretion of hormones, peptides, enzymes and neurotransmitters into the external medium occurs when mature secretory granules fuse with the plasma membrane. Secretory granules form at the trans-Golgi network (TGN) by envelopment of the dense-core aggregate of regulated secretory proteins by a specific membrane. The secretory granules initially formed at the TGN, referred to here as immature secretory granules, are morphologically and biochemically distinct from mature secretory granules. The functional similarities and differences between the immature secretory granule and the mature secretory granule, and the events involved in the maturation of the secretory granules are briefly discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tooze SAdoi
10.1016/0014-5793(91)80805-dsubject
Has Abstractpub_date
1991-07-22 00:00:00pages
220-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80805-Djournal_volume
285pub_type
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