Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.


:LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial gene expression of the dopaminergic pathway, and evidence shows they are also involved in adult neuronal homeostasis. In this review, the multiple roles played by Lmx1a and Lmx1b will be discussed. Controlled Lmx1a and Lmx1b expression and activities ensure the proper formation of critical signaling centers, including the embryonic ventral mesencephalon floor plate and sharp boundaries between lineage-specific cells. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area, and their role in the adult brain is beginning to be revealed. Notably, LMX1B expression was lower in brain tissue affected by Parkinson's disease. Actual and future applications of Lmx1a and Lmx1b transcription factors in stem cell production as well as in direct conversion of fibroblast into dopaminergic neurons are also discussed. A thorough understanding of the role of LMX1A and LMX1B in a number of disease states, including developmental diseases, cancer and neurodegenerative diseases, could lead to significant benefits for human healthcare.




FEBS letters


Doucet-Beaupré H,Ang SL,Lévesque M




Has Abstract


2015-12-21 00:00:00




24 Pt A










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    abstract::We review the evidence for H+ translocation by reconstituted cytochrome c oxidase; attention is paid to those aspects which we feel most open to criticism. Possible alternative hypotheses are assessed, with regard to experiments carried out to test them directly and with regard to published data. We conclude that, whi...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Casey RP,Azzi A

    更新日期:1983-04-18 00:00:00

  • Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential.

    abstract::To test if mitochondrial uncoupling in white adipocytes is responsible for obesity resistance of the aP2-Ucp transgenic mice expressing ectopic uncoupling protein 1 (UCPI) in white fat, mitochondrial membrane potential (delta psi(m)) was estimated by flow cytometry in adipocytes isolated from gonadal fat. Ectopic UCP1...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Baumruk F,Flachs P,Horáková M,Floryk D,Kopecký J

    更新日期:1999-02-12 00:00:00

  • Collagenase in mineralized tissues of human teeth.

    abstract::A collagenase cleaving native type I [14C]collagen but inactive against the synthetic substrate Pz-Pro-Leu-Gly-Pro-D-Arg was extracted from mineralized human dental tissue. The enzyme specifically degrades native collagen into characteristic products (3/4) and (1/4). Its apparent molecular mass of 68 kDa is relatively...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dumas J,Hurion N,Weill R,Keil B

    更新日期:1985-07-22 00:00:00

  • Protein-based phylogenetic analysis by using hydropathy profile of amino acids.

    abstract::So far, various approaches for phylogenetic analysis have been developed. Almost all of them put stress on analyzing nucleic acid sequences or protein primary structures. In this paper, we take the physicochemical properties of amino acids into account and introduce the hydropathy profile of amino acids into phylogene...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Liu N,Wang T

    更新日期:2006-10-02 00:00:00

  • Translational control of terminal oligopyrimidine mRNAs requires a specific regulator.

    abstract::Terminal oligopyrimidine (TOP) mRNAs are a group of messengers translationally regulated according to the growth status of the cell. Two hypotheses have been proposed for the mechanism of the regulation: (i) there is a specific translational regulator which can reversibly alter TOP-mRNA structure, (ii) a component of ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Loreni F,Amaldi F

    更新日期:1997-10-27 00:00:00

  • Sequence analysis of the cloned streptococcal cell surface antigen I/II.

    abstract::The gene spa P (formerly designated as spa P1) encoding the Mr 185,000 surface antigen (I/II) of Streptococcus mutans, serotype c (NG5), has been sequenced. The gene (4683 bp) encodes a protein of 1561 amino acid residues including putative signal peptide (residues 1-38) and transmembrane (residues 1537-1556) sequence...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kelly C,Evans P,Bergmeier L,Lee SF,Progulske-Fox A,Harris AC,Aitken A,Bleiweis AS,Lehner T

    更新日期:1989-11-20 00:00:00

  • Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2.

    abstract::The neopterin derivatives, neopterin and 7,8-dihydroneopterin, modulate the cellular oxidant-antioxidant balance as well as the expression of the inducible nitric oxide synthase (iNOS) gene. Since apoptosis can be induced by reactive oxygen intermediates and nitric oxide (NO) we investigated whether these neopterin de...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Schobersberger W,Hoffmann G,Hobisch-Hagen P,Bock G,Volkl H,Baier-Bitterlich G,Wirleitner B,Wachter H,Fuchs D

    更新日期:1996-11-18 00:00:00

  • Mutations in the amino-terminal domain of the human poly(ADP-ribose) polymerase that affect its catalytic activity but not its DNA binding capacity.

    abstract::Poly-ADP ribosylation of nuclear proteins is activated when poly(ADP-ribose) polymerase (PARP), a nuclear zinc-finger enzyme, binds to single-strand DNA breaks. To understand how the signal emerging from its DNA-binding domain (DBD) bound to such breaks is transduced to its catalytic domain, the structure-function rel...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Trucco C,Flatter E,Fribourg S,de Murcia G,Ménissier-de Murcia J

    更新日期:1996-12-16 00:00:00

  • Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I).poly(C) in human amnion cells (UAC).

    abstract::Polyinosinic-polycytidylic acid, a potent inducer of inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and act...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Premecz G,Markovits A,Bagi G,Farkas T,Földes I

    更新日期:1987-12-21 00:00:00

  • Cold denaturation of yeast phosphoglycerate kinase: which domain is more stable?

    abstract::Under destabilising conditions both heat and cold denaturation of yeast phosphoglycerate kinase (PGK) can be observed. According to previous interpretation of experimental data and theoretical calculations, the C-terminal domain should be more stable than the N-terminal domain at all temperatures. We report on thermal...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gast K,Damaschun G,Desmadril M,Minard P,Müller-Frohne M,Pfeil W,Zirwer D

    更新日期:1995-01-30 00:00:00

  • Oxytocin induced cAMP-dependent protein kinase activation and urokinase-type plasminogen activator production in LLC-PK1 renal epithelial cells is mediated by the vasopressin V2-receptor.

    abstract::Using a variety of peptide analogues of oxytocin (OT) and Arg8-vasopressin (AVP), OT-mediated induction of urokinase-type plasminogen activator (uPA) was examined in LLC-PK1 renal epithelial cells, which possess distinct high-affinity receptors of both the OT- and vasopressin renal (V2-) types. OT or OT-receptor speci...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Jans DA,Pavo I,Fahrenholz F

    更新日期:1993-01-04 00:00:00

  • Prokaryotic 20 beta-hydroxysteroid dehydrogenase is an enzyme of the 'short-chain, non-metalloenzyme' alcohol dehydrogenase type.

    abstract::The primary structure of 20 beta-hydroxysteroid dehydrogenase from Streptomyces hydrogenans was determined after FPLC purification of a commercial preparation. Peptides obtained from different proteolytic cleavages were purified by reverse phase HPLC. The 255-residue structure deduced was found to be distantly homolog...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Marekov L,Krook M,Jörnvall H

    更新日期:1990-06-18 00:00:00

  • Characterization of the RDC1 gene which encodes the canine homolog of a proposed human VIP receptor. Expression does not correlate with an increase in VIP binding sites.

    abstract::We have isolated a portion of the canine gene encoding the orphan receptor RDC1 [1]. The complete coding sequence is contained in a single exon, and an intron divides the 5' untranslated region of RDC1 mRNA. The RDC1 protein is 94% homologous to the gene product of GPRN1, which has been proposed to serve as a VIP rece...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Cook JS,Wolsing DH,Lameh J,Olson CA,Correa PE,Sadee W,Blumenthal EM,Rosenbaum JS

    更新日期:1992-03-30 00:00:00

  • Developmental regulation of expression of the alpha 1 and alpha 2 subunits mRNAs of the voltage-dependent calcium channel in a differentiating myogenic cell line.

    abstract::The voltage-dependent calcium channel (VDCC) in skeletal muscle probably plays a key role in transducing membrane charge movement to the calcium release channel. We report here that the expression of VDCC alpha 1 and alpha 2 mRNAs is developmentally regulated in differentiating C2C12 myogenic cells. The alpha 1 mRNA i...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Varadi G,Orlowski J,Schwartz A

    更新日期:1989-07-03 00:00:00

  • Relaxation study of the backbone dynamics of human profilin by two-dimensional 1H-15N NMR.

    abstract::The dynamic properties of 111 backbone HN sites in uncomplexed human profilin, a protein of 139 residues, have been characterized by two-dimensional inverse-detected 1H-15N NMR spectroscopy. Heteronuclear (1H)-15N nuclear Overhauser effects and 15N longitudinal and transverse relaxation rates have been analyzed in ter...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Constantine KL,Friedrichs MS,Bell AJ,Lavoie TB,Mueller L,Metzler WJ

    更新日期:1993-12-28 00:00:00

  • The nuclear-encoded 18 kDa (IP) AQDQ subunit of bovine heart complex I is phosphorylated by the mitochondrial cAMP-dependent protein kinase.

    abstract::In bovine heart mitochondria a protein of M(r) 18 kDa, phosphorylated by mtPKA, is associated to the NADH-ubiquinone oxidoreductase in the inner membrane and is present in purified preparation of this complex. The 18 kDa phosphoprotein has now been isolated and sequenced. It is identified as the 18 kDa (IP) AQDQ subun...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Papa S,Sardanelli AM,Cocco T,Speranza F,Scacco SC,Technikova-Dobrova Z

    更新日期:1996-02-05 00:00:00

  • Binding of a de novo designed peptide to specific glycosaminoglycans.

    abstract::The binding of glycosaminoglycans to a synthetic peptide (SKAQKAQAKQAKQAQKAQKAQAKQAKQW-CONH(2)), consisting of a hybrid consensus heparin binding sequence, is studied using circular dichroism, fluorescence anisotropy and nuclear magnetic resonance techniques. The results unveil certain novel features, most importantly...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Jayaraman G,Wu CW,Liu YJ,Chien KY,Fang JC,Lyu PC

    更新日期:2000-09-29 00:00:00

  • Nuclear bile acid receptor FXR as pharmacological target: are we there yet?

    abstract::The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is primarily expressed in the enterohepatic system where it functions as intracellular sensor for bile acids. Ligand dependent FXR activation induces transcriptional responses to coordinately regulate bile acid, cholesterol, triglyceri...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Modica S,Moschetta A

    更新日期:2006-10-09 00:00:00

  • Evidence for a dynamic role of the linker histone variant H1x during retinoic acid-induced differentiation of NT2 cells.

    abstract::The dynamics of chromatin structure are tightly regulated by multiple epigenetic mechanisms such as histone modifications and incorporation of histone variants. In the current work, differentiation of an embryonal carcinoma cell line, NT2, was induced by retinoic acid, and total histone proteins were compared througho...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Shahhoseini M,Favaedi R,Baharvand H,Sharma V,Stunnenberg HG

    更新日期:2010-11-19 00:00:00

  • An amino acid substitution that blocks the deacylation step in the enzyme mechanism of penicillin-binding protein 5 of Escherichia coli.

    abstract::A mutant of Escherichia coli has been described that produces an altered form of penicillin-binding protein 5 which still binds penicillin but is unable to catalyse the release of the bound penicilloyl moiety. We show that the mutation is caused by a single nucleotide transition that results in a change from glycine a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Broome-Smith J,Spratt BG

    更新日期:1984-01-09 00:00:00

  • Peculiarities of immunoglobulin gene structures as a basis for somatic mutation emergence.

    abstract::Using the method of contextual analysis, we have studied the collection of somatic mutations in immunoglobulin genes. It has been found that the emergence of somatic mutations can be based on the reparation of complementarity violations in the heteroduplexes corresponding to complementary palindromes or direct repeats...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kolchanov NA,Solovyov VV,Rogozin IB

    更新日期:1987-04-06 00:00:00

  • Effect of drugs, peptide hormones and lipogenic precursors on the relative incorporation of [3H]H2O and carbon into hepatic cholesterol.

    abstract::Measurement of the weight of desmosterol produced during its biosynthesis in the presence of tritiated water and triparanol has permitted a direct determination of the relative flux of carbon and tritium (the H/C ratio) into sterol in hepatocytes. The H/C ratio increased with time of incubation irrespective of the nut...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Björnsson OG,Pullinger CR,Gibbons GF

    更新日期:1985-08-05 00:00:00

  • An improved purification of lactose permease.

    abstract::The integral membrane protein lactose permease of Escherichia coli was purified to homogeneity in detergent micelles. No other proteins could be detected in the final product. The molar ratio of lactose permease to lipid was less than 0.2 in detergent solution, thus the preparation was essentially lipid-free. All mole...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dornmair K

    更新日期:1988-08-01 00:00:00

  • The environments of Trp-248 and Trp-330 in tryptophan indole-lyase from Escherichia coli.

    abstract::The two tryptophan residues, Trp-248 and Trp-330, in tryptophan indole-lyase (tryptophanase) from E. coli have been separately mutated to phenylalanine using site-directed mutagenesis. Both single tryptophan mutant enzymes have full catalytic activity, but exhibit different fluorescence and near-UV circular dichroism ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Phillips RS,Gollnick P

    更新日期:1990-07-30 00:00:00

  • Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A.

    abstract::Superoxide reacts with nitric oxide to form peroxynitrite, a potent oxidising agent which may contribute to tissue damage in pathological situations such as inflammation and ischaemia/reperfusion. One mechanism by which oxidative stress damages tissues is the induction of a specific Cyclosporin A-sensitive mitochondri...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Packer MA,Murphy MP

    更新日期:1994-05-30 00:00:00

  • Transcriptional changes in response to growth of Arabidopsis in high external calcium.

    abstract::Transcriptional responses to growth in high environmental calcium concentrations were characterized and compared between wild-type and mutant Arabidopsis plants containing a knockout mutation in the gene encoding a cyclic nucleotide-gated channel (CNGC2). We show that the transcriptional profile of cngc2 plants grown ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chan CW,Wohlbach DJ,Rodesch MJ,Sussman MR

    更新日期:2008-03-19 00:00:00

  • Homing markers for atherosclerosis: applications for drug delivery, gene delivery and vascular imaging.

    abstract::Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1 beta and tumour necrosis factor alpha activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in vivo biopann...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Houston P,Goodman J,Lewis A,Campbell CJ,Braddock M

    更新日期:2001-03-09 00:00:00

  • Fluorescence ratiometric detection of ligand-induced receptor internalization using extracellular coiled-coil tag-probe labeling.

    abstract::We report a new method for the detection of ligand-induced receptor internalization by fluorescence ratiometric imaging of pH in endosomes in combination with a recently developed posttranslational labeling system based on the formation of a heterodimeric coiled-coil structure. The N-terminus of the β2-adrenergic rece...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yano Y,Matsuzaki K

    更新日期:2011-07-21 00:00:00

  • Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues.

    abstract::The immunosuppressive agent FK-506 has received much attention due to its efficacy and potency in the areas of transplant rejection and autoimmune disease. Calcineurin, a Ca(2+)-calmodulin activated phosphatase, was recently implicated in the immunosuppressive mechanism of FK-506. In our ongoing search for superior im...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kawai M,Lane BC,Hsieh GC,Mollison KW,Carter GW,Luly JR

    更新日期:1993-01-25 00:00:00

  • The shapes and sizes of two domains of tropomodulin, the P-end-capping protein of actin-tropomyosin.

    abstract::Tropomodulin, the P-end (slow-growing end)-capping protein of the actin-tropomyosin filament, and its fragment (C20) of the C-terminal half were studied by synchrotron small-angle X-ray scattering, restoring low-resolution shapes using an ab initio shape-determining procedure. Tropomodulin is elongated (115 A long) an...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Fujisawa T,Kostyukova A,Maéda Y

    更新日期:2001-06-01 00:00:00