Abstract:
:USP4, 11 and 15 are three closely related paralogues of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. The DUSP domain and the UBL domain in these proteins are juxtaposed which may provide a functional unit conferring specificity. We determined the structures of the USP15 DUSP-UBL double domain unit in monomeric and dimeric states. We then conducted comparative analysis of the structural and physical properties of all three DUSP-UBL units. We identified structural features that dictate different dispositions between constituent domains, which in turn may influence respective binding properties.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Elliott PR,Liu H,Pastok MW,Grossmann GJ,Rigden DJ,Clague MJ,Urbé S,Barsukov ILdoi
10.1016/j.febslet.2011.09.040subject
Has Abstractpub_date
2011-11-04 00:00:00pages
3385-90issue
21eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00737-Xjournal_volume
585pub_type
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