Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation.

Abstract:

:Ribonucleoprotein complexes, which contain mRNAs and their regulator proteins, carry out post-transcriptional control of gene expression. The function of many RNA-binding proteins depends on their association with cofactors. Here, we use a genomic approach to identify transcripts associated with DLC-1, a protein previously identified as a cofactor of two unrelated RNA-binding proteins that act in the Caenorhabditis elegans germline. Among the 2732 potential DLC-1 targets, most are germline mRNAs associated with oogenesis. Removal of DLC-1 affects expression of its targets expressed in the oocytes, meg-1 and meg-3. We propose that DLC-1 acts as a cofactor for multiple ribonucleoprotein complexes, including the ones regulating gene expression during oogenesis.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Day NJ,Ellenbecker M,Voronina E

doi

10.1002/1873-3468.13259

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

3683-3695

issue

22

eissn

0014-5793

issn

1873-3468

journal_volume

592

pub_type

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