Prorenin processing by cathepsin B in vitro and in transfected cells.

abstract：:Low-density lipoprotein receptor-related protein 4 (Lrp4) is essential for pre- and post-synaptic specialization at the neuromuscular junction (NMJ), an indispensable synapse between a motor nerve and skeletal muscle. Muscle-specific receptor tyrosine kinase MuSK must form a complex with Lrp4 to organize postsynaptic ...

journal_title：FEBS letters

authors： Hoshi T,Tezuka T,Yokoyama K,Iemura S,Natsume T,Yamanashi Y

更新日期：2013-11-29 00:00:00

abstract：:The toxicity of the beta-amyloid (Abeta) peptide of Alzheimer's disease may relate to its polymerisation state (i.e. fibril content). We have shown previously that plasma lipoproteins, particularly when oxidised, greatly enhance Abeta polymerisation. In the present study the nature of the interactions between both nat...

journal_title：FEBS letters

authors： Stanyer L,Betteridge DJ,Smith CC

更新日期：2002-05-08 00:00:00

abstract：:Glutamate uptake by rat hepatocytes in primary monolayer culture was found to be mediated by a Na+-independent and by two Na+-dependent transport systems of high and low affinity. Inhibition studies with cysteate and other model amino acids rules out the participation of the neutral amino acid transport systems A, ASC...

journal_title：FEBS letters

authors： Gebhardt R,Mecke D

更新日期：1983-09-19 00:00:00

abstract：:We established a medium-scale real-time RT-PCR system focusing on transcription factors and applied it to their expression profiles in the adult mouse 11 brain regions (http://genome.gsc.riken.jp/qRT-PCR/). Almost 90% of the examined genes showed significant expression in at least one region. We successfully extracted...

journal_title：FEBS letters

authors： Suzuki H,Okunishi R,Hashizume W,Katayama S,Ninomiya N,Osato N,Sato K,Nakamura M,Iida J,Kanamori M,Hayashizaki Y

更新日期：2004-08-27 00:00:00

abstract：:Acceptor stem variants of tRNA(fMet) (Escherichia coli) have been characterized by nuclear magnetic resonance. The wild type contains a C1-A72 mismatch pair which is crucial for its biological function. For comparison, the mismatch was replaced by regular pairs U1-A72 and C1-G72. Further variants contain an altered di...

journal_title：FEBS letters

authors： Zuleeg T,Vogtherr M,Schübel H,Limmer S

更新日期：2000-04-28 00:00:00

abstract：:The C-Jun N-terminal Kinase (JNK) inhibitor SP600125 is widely used to inhibit the JNK-mediated Bax activation and cell apoptosis. However, this report demonstrates that SP600125 synergistically enhances the dihydroartemisinin (DHA)-induced human lung adenocarcinoma cell apoptosis by accelerating Bax translocation and...

journal_title：FEBS letters

authors： Lu YY,Chen TS,Wang XP,Qu JL,Chen M

更新日期：2010-09-24 00:00:00

abstract：:We have studied the interaction of the yeast RAS2 protein with guanine nucleotides using energetic parameters for the dissociation of RAS.nucleotide complexes. The results indicated that a Gly-->Ser substitution at position 82 led to an altered interaction with GppNHp and, to a lesser extent, also with GDP. It was als...

journal_title：FEBS letters

authors： De Vendittis E,Fasano O

更新日期：1994-06-27 00:00:00

abstract：:The relationship between different amino acids at the beta 6 position of hemoglobin and tetramer stability was addressed by a site-directed mutagenesis approach. Precipitation rates during mechanical agitation of oxyhemoglobins with Gln, Ala, Val, Leu and Trp at the beta 6 position increased 2, 5, 13, 21 and 53 times,...

journal_title：FEBS letters

authors： Adachi K,Kim JY,Konitzer P,Asakura T,Saviola B,Surrey S

更新日期：1993-01-02 00:00:00

abstract：:Endothelial cells play a pivotal role in the development of atherosclerosis. An 'activated' phenotype of these cells is manifested by signal transduction-dependent expression of genes encoding cytokines, pro- and anticoagulant factors, and cell adhesion molecules. In the current study we examined the effect of ouabain...

journal_title：FEBS letters

authors： Bereta J,Cohen MC,Bereta M

更新日期：1995-12-11 00:00:00

abstract：:The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in Drosophila neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion and water permeability of Bib. The adhesive function was examined by a cell aggregation assay usi...

journal_title：FEBS letters

authors： Tatsumi K,Tsuji S,Miwa H,Morisaku T,Nuriya M,Orihara M,Kaneko K,Okano H,Yasui M

更新日期：2009-06-18 00:00:00

abstract：:The possible regulation of the expression of uncoupling protein-2 (UCP2) mRNA by thyroid hormones in different tissues was examined in rats. Triiodothyronine (T3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues. The effect of T3 was markedly observed in heart, whereas a moderate ef...

journal_title：FEBS letters

authors： Lanni A,De Felice M,Lombardi A,Moreno M,Fleury C,Ricquier D,Goglia F

更新日期：1997-11-24 00:00:00

abstract：:In photosynthetic reaction centers, the excitation with light leads to the formation of a charge separated state across the photosynthetic membrane. For the reaction center of purple non-sulphur bacteria, it was previously generally assumed that this primary charge separation could only start with the excitation of th...

journal_title：FEBS letters

authors： van Brederode ME,van Grondelle R

更新日期：1999-07-16 00:00:00

abstract：:To evaluate the involvement of protein phosphatases (PP) in differentiation of human myelogenous leukemia HL-60 cells, we made use of potent inhibitors of PP1 and PP2A, calyculin-A (CAL-A) and okadaic acid (OKA). CAL-A and OKA could augment all-trans retinoic acid (ATRA)-induced granulocytic differentiation, whereas t...

journal_title：FEBS letters

authors： Morita K,Nishikawa M,Kobayashi K,Deguchi K,Ito M,Nakano T,Shima H,Nagao M,Kuno T,Tanaka C

更新日期：1992-12-21 00:00:00

abstract：:The crystal structure of Arthromyces ramosus peroxidase (ARP) in complex with benzhydroxamic acid (BHA) as determined by X-ray analysis at 1.6 A shows unambiguously how BHA binds to ARP. BHA is located in the distal heme pocket. Its functional groups are held by three hydrogen bonds to His56N(epsilon), Arg52N(epsilon)...

journal_title：FEBS letters

authors： Itakura H,Oda Y,Fukuyama K

更新日期：1997-07-21 00:00:00

abstract：:Using an all-atom, molecular dynamics-based, flexible docking method, the tertiary and quaternary structures of protofilaments of the "K3" fragment from beta(2)-microglobulin (residues Ser20-Lys41) were predicted at low pH in a continuous mixture of water and 2,2,2-trifluoroethanol (TFE). Tetramers with energies very ...

journal_title：FEBS letters

authors： Standley DM,Yonezawa Y,Goto Y,Nakamura H

更新日期：2006-11-13 00:00:00

abstract：:MiR-140 is a microRNA specially involved in chondrogenesis and osteoarthritis pathogenesis. However, its transcriptional regulation and target genes in cartilage development are not fully understood. Here we detected that miR-140 was uniquely expressed in chondrocyte and suppressed by Wnt/β-catenin signalling. The miR...

journal_title：FEBS letters

authors： Yang J,Qin S,Yi C,Ma G,Zhu H,Zhou W,Xiong Y,Zhu X,Wang Y,He L,Guo X

更新日期：2011-10-03 00:00:00

abstract：:Formation of tubulin/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. More...

journal_title：FEBS letters

authors： Amaiden MR,Santander VS,Monesterolo NE,Nigra AD,Rivelli JF,Campetelli AN,Pie J,Casale CH

更新日期：2015-01-30 00:00:00

abstract：:Extracellular vesicles (EVs) contain microRNAs (miRNAs). However, the exact molecular mechanisms of the recruitment of miRNAs in EVs are not well characterized. Based on proteomic analysis, we identified that silencing of Annexin A2 (ANXA2) significantly decreased the amount of miRNAs in EVs. In addition, microarray a...

journal_title：FEBS letters

authors： Hagiwara K,Katsuda T,Gailhouste L,Kosaka N,Ochiya T

更新日期：2015-12-21 00:00:00

abstract：:On April 1898 Camillo Golgi communicated to the Medical-Surgical Society of Pavia, the discovery of the "internal reticular apparatus", a novel intracellular organelle which he observed in nerve cells with the silver impregnation he had introduced for the staining of the nervous system. Soon after the discovery it bec...

journal_title：FEBS letters

authors： Mazzarello P,Garbarino C,Calligaro A

更新日期：2009-12-03 00:00:00

abstract：:In cooperative aggregation of bovine platelets induced by simultaneous addition of PAF and collagen at subthreshold concentrations the following observations were made. (i) Formation of phosphatidic acid and arachidonic acid metabolites, which characterize PAF and collagen alone-induced aggregation, respectively, was ...

journal_title：FEBS letters

authors： Kojima S,Sekiya F,Inada Y,Sato F,Tsukada T,Saito Y

更新日期：1990-07-16 00:00:00

abstract：:The structure of the dimeric C-terminal domain of the HIV-1 capsid protein (CA), recently determined by X-ray crystallography (Gamble et al. (1997)), has a notable resemblance to the structure of the hepatitis B virus (HBV) capsid protein (Cp) dimer, previously determined by cryo-electron microscopy (Conway et al. (19...

journal_title：FEBS letters

authors： Zlotnick A,Stahl SJ,Wingfield PT,Conway JF,Cheng N,Steven AC

更新日期：1998-07-24 00:00:00

abstract：:We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containi...

journal_title：FEBS letters

authors： Sano S,Ohnishi H,Omori A,Hasegawa J,Kubota M

更新日期：1997-07-14 00:00:00

abstract：:Lectin-like oxidized low-density lipoprotein receptor (LOX-1) is a scavenger receptor that binds oxidized low-density lipoprotein (OxLDL) and has a role in atherosclerosis development. The N-terminus intracellular region (cytoplasmic domain) of LOX-1 mediates receptor internalization and trafficking, potentially throu...

journal_title：FEBS letters

authors： Bakthavatsalam D,Soung RH,Tweardy DJ,Chiu W,Dixon RA,Woodside DG

更新日期：2014-06-13 00:00:00

abstract：:Macrophages contain arginase and an inducible NO synthase, demonstrated by using L-arginine, the common substrate, for production of both nitric oxide and urea. Arginase was inhibited by nitrite, the stable end product of NO. This inhibition was non-competitive, and could not be explained by the reaction of nitrite wi...

journal_title：FEBS letters

authors： Hrabák A,Bajor T,Temesi A,Mészáros G

更新日期：1996-07-22 00:00:00

abstract：:Stable liposomes were rendered pH-sensitive by complexation to a polymer that undergoes marked temperature- and pH-dependent water solubility changes. The N-isopropylacrylamide-methacrylic acid copolymer was prepared with or without octadecyl acrylate. At pH below the phase transition of the polymer, egg phosphatidylc...

journal_title：FEBS letters

authors： Meyer O,Papahadjopoulos D,Leroux JC

更新日期：1998-01-02 00:00:00

abstract：:This article presents an overview of the simulation studies of the behaviour of multihaem cytochromes using theoretical/computational methodologies, with an emphasis on cytochrome c(3). It starts with the first studies using rigid molecules and continuum electrostatic models, where protonation and redox events were tr...

journal_title：FEBS letters

authors： Soares CM,Baptista AM

更新日期：2012-03-09 00:00:00

abstract：:c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcri...

journal_title：FEBS letters

authors： Nasi S,Ciarapica R,Jucker R,Rosati J,Soucek L

更新日期：2001-02-16 00:00:00

abstract：:Structural analogs of adenosine 5'-acylphosphates, which are intermediates of the reaction catalyzed by acyl-CoA synthetases, were synthesized by condensing primary alcohols with AMP to examine the inhibitory effects on the lignoceroyl-CoA and palmitoyl-CoA synthetase activities. Hexadecyl, octadecyl, eicosyl, docosyl...

journal_title：FEBS letters

authors： Shiraishi T,Tezuka K,Uda Y

更新日期：1994-10-03 00:00:00

abstract：:The nucleotide sequence of the genomic RNA of potato leafroll virus was determined and its genetic organization deduced. The RNA is 5882 nucleotides long and contains 6 open reading frames (ORFs) encoding proteins of 70, 70, 56, 28, 23 and 17 kDa. The putative genes for the coat protein (23 kDa) and the RNA-dependent ...

journal_title：FEBS letters

authors： van der Wilk F,Huisman MJ,Cornelissen BJ,Huttinga H,Goldbach R

更新日期：1989-03-13 00:00:00

abstract：:Lysine-rich phosphorylated cystatin alpha (P-cystatin alpha) from newborn rat epidermis is a good substrate for epidermal transglutaminase (TGase) and also one of the component proteins of cornified envelope in the stratum corneum. Since the filaggrin linker segment peptide was efficiently conjugated with P-cystatin a...

journal_title：FEBS letters

authors： Takahashi M,Tezuka T,Kakegawa H,Katunuma N

更新日期：1994-03-07 00:00:00