Abstract:
:We established a medium-scale real-time RT-PCR system focusing on transcription factors and applied it to their expression profiles in the adult mouse 11 brain regions (http://genome.gsc.riken.jp/qRT-PCR/). Almost 90% of the examined genes showed significant expression in at least one region. We successfully extracted 179 region-specific genes by clustering analysis. Interestingly, the transcription factors involved in the development of the pituitary were still expressed in the adult pituitary, suggesting that they also play important roles in maintenance of the pituitary. These results provide unique molecular markers that may account for the molecular basis of the unique functions of specific brain regions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Suzuki H,Okunishi R,Hashizume W,Katayama S,Ninomiya N,Osato N,Sato K,Nakamura M,Iida J,Kanamori M,Hayashizaki Ydoi
10.1016/j.febslet.2004.07.068keywords:
subject
Has Abstractpub_date
2004-08-27 00:00:00pages
214-8issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579304009640journal_volume
573pub_type
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