Abstract:
:In cooperative aggregation of bovine platelets induced by simultaneous addition of PAF and collagen at subthreshold concentrations the following observations were made. (i) Formation of phosphatidic acid and arachidonic acid metabolites, which characterize PAF and collagen alone-induced aggregation, respectively, was observed very obviously. (ii) A thromboxane antagonist did not completely block the cooperative aggregation. The extent of residual aggregation activity was dependent on concentration of collagen used in the simultaneous administration with PAF. These results suggest that both signal transduction pathways activated by PAF and collagen alone at high concentrations are attained by simultaneous addition of both agonists at subthreshold concentrations through unknown mechanisms.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kojima S,Sekiya F,Inada Y,Sato F,Tsukada T,Saito Ydoi
10.1016/0014-5793(90)80930-hsubject
Has Abstractpub_date
1990-07-16 00:00:00pages
226-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80930-Hjournal_volume
267pub_type
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