Abstract:
:In hepatocytes from control rats, the ureogenic action of epinephrine is mainly mediated through alpha 1-adrenoceptors and the effect is independent of the presence of extracellular calcium. In hepatocytes from adrenalectomized rats, both alpha 1- and beta-adrenoceptors are involved in the action of epinephrine. Furthermore, the alpha 1-adrenergic-mediated stimulation of ureogenesis in these cells is dependent on the presence of extracellular calcium. Our results indicate that glucocorticoids modulate the calcium dependency of alpha 1-adrenergic effects and are consistent with our suggestion that two pathways are involved in the transduction of the alpha 1-adrenergic signal.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hernández-Sotomayor SM,García-Sáinz JAdoi
10.1016/0014-5793(84)80118-0subject
Has Abstractpub_date
1984-01-30 00:00:00pages
385-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(84)80118-0journal_volume
166pub_type
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