Abstract:
:We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hwang MG,Chung IK,Kang BG,Cho MHdoi
10.1016/s0014-5793(01)02685-0keywords:
subject
Has Abstractpub_date
2001-08-10 00:00:00pages
35-40issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02685-0journal_volume
503pub_type
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