Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1).

Abstract:

:We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Hwang MG,Chung IK,Kang BG,Cho MH

doi

10.1016/s0014-5793(01)02685-0

keywords:

subject

Has Abstract

pub_date

2001-08-10 00:00:00

pages

35-40

issue

1

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(01)02685-0

journal_volume

503

pub_type

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