Abstract:
:The role of retinoic acids (RA) on liver fatty acid-binding protein (L-FABP) expression was investigated in the well differentiated FAO rat hepatoma cell line. 9-cis-Retinoic acid (9-cis-RA) specifically enhanced L-FABP mRNA levels in a time- and dose-dependent manner. The higher induction was found 6 h after addition of 10(-6) M 9-cis-RA in the medium. RA also enhanced further both L-FABP mRNA levels and cytosolic L-FABP protein content induced by oleic acid. The retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor (PPAR), which are known to be activated, respectively, by 9-cis-RA and long chain fatty acid (LCFA), co-operated to bind specifically the peroxisome proliferator-responsive element (PPRE) found upstream of the L-FABP gene. Our result suggest that the PPAR-RXR complex is the molecular target by which 9-cis-RA and LCFA regulate the L-FABP gene.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Poirier H,Braissant O,Niot I,Wahli W,Besnard Pdoi
10.1016/s0014-5793(97)00830-2subject
Has Abstractpub_date
1997-08-04 00:00:00pages
480-4issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00830-2journal_volume
412pub_type
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