Abstract:
:S100 beta is a neurite extension factor and has been implicated in Alzheimer's disease and Down's syndrome. It belongs to a group of low molecular weight calcium-binding proteins containing the helix-loop-helix calcium binding motif. The structure of only one S100 protein, calbindin D9k, which has the lowest sequence similarity to the other members of the S100 group has been determined. We report the NMR assignments and secondary structure of calcium-free S100 beta. The secondary structure is similar to that of calbindin D9k, determined using NMR, except that there is clear evidence for an additional well ordered 5-residue alpha-helix in S100 beta.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kilby PM,Van Eldik LJ,Roberts GCdoi
10.1016/0014-5793(95)00296-lsubject
Has Abstractpub_date
1995-04-17 00:00:00pages
90-6issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(95)00296-Ljournal_volume
363pub_type
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