Abstract:
:Pleckstrin homology (PH) domains are protein modules found in proteins involved in many cellular processes. The majority of PH domain-containing proteins require membrane association for their function. It has been shown that most PH domains interact directly with the cell membrane by binding to phosphoinositides with a broad range of specificity and affinity. While a highly specific binding of the PH domain to a phosphoinositide can be necessary and sufficient for the correct recruitment of the host protein to the membrane, a weaker and less specific interaction may be necessary but not sufficient, thus probably requiring alternative, co-operative mechanisms.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Maffucci T,Falasca Mdoi
10.1016/s0014-5793(01)02909-xkeywords:
subject
Has Abstractpub_date
2001-10-12 00:00:00pages
173-9issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02909-Xjournal_volume
506pub_type
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