Abstract:
:The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein-protein interactions. We have identified Saccharomyces cerevisiae Tom72, a new Tom protein expressed at a low level. Tom72 is homologous to Tom 70, including seven tetratrico peptide repeats. Tom72 is targeted to the mitochondrial outer membrane, forms a large domain exposed to the cytosol and loosely associates with the translocase complex of the outer membrane. These results suggest that Tom72 represents a ninth, weakly expressed component of the preprotein translocase of the mitochondrial outer membrane.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bömer U,Pfanner N,Dietmeier Kdoi
10.1016/0014-5793(96)00156-1subject
Has Abstractpub_date
1996-03-11 00:00:00pages
153-8issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(96)00156-1journal_volume
382pub_type
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