Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats.

Abstract:

:The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein-protein interactions. We have identified Saccharomyces cerevisiae Tom72, a new Tom protein expressed at a low level. Tom72 is homologous to Tom 70, including seven tetratrico peptide repeats. Tom72 is targeted to the mitochondrial outer membrane, forms a large domain exposed to the cytosol and loosely associates with the translocase complex of the outer membrane. These results suggest that Tom72 represents a ninth, weakly expressed component of the preprotein translocase of the mitochondrial outer membrane.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Bömer U,Pfanner N,Dietmeier K

doi

10.1016/0014-5793(96)00156-1

subject

Has Abstract

pub_date

1996-03-11 00:00:00

pages

153-8

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(96)00156-1

journal_volume

382

pub_type

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