Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats.


:The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein-protein interactions. We have identified Saccharomyces cerevisiae Tom72, a new Tom protein expressed at a low level. Tom72 is homologous to Tom 70, including seven tetratrico peptide repeats. Tom72 is targeted to the mitochondrial outer membrane, forms a large domain exposed to the cytosol and loosely associates with the translocase complex of the outer membrane. These results suggest that Tom72 represents a ninth, weakly expressed component of the preprotein translocase of the mitochondrial outer membrane.




FEBS letters


Bömer U,Pfanner N,Dietmeier K




Has Abstract


1996-03-11 00:00:00














  • Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock.

    abstract::Polyamine depletion, obtained in FAO cells with specific inhibitors of biosynthetic enzymes, prevents or decreases the accumulation of hsp 70 mRNA following heat shock [Desiderio et al., Hepatology 24 (1996) 150-156]. The present study shows that under conditions of spermidine depletion caused by alpha-difluoromethylo...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Desiderio MA,Dansi P,Tacchini L,Bernelli-Zazzera A

    更新日期:1999-07-16 00:00:00

  • PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1).

    abstract::Serine/threonine phosphatases such as PP1, PP2A, and PP2B are well known to regulate the transition phase of the cell cycle. However, the function of PP2Cgamma in cell cycle progression is still unclear. In the present study, we report the characterization of PP2Cgamma in mammalian cells during the cell cycle. After r...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Suh EJ,Kim TY,Kim SH

    更新日期:2006-11-13 00:00:00

  • STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.

    abstract::STAT4 is a transcription factor activated in response to IL-12, and is involved in Th1 cell development. The molecular mechanisms controlling the transcription of the STAT4 gene are however, unclear. Sequence comparison of the 5' flanking regions of human, mouse and pufferfish (Fugu rubripes) Stat4 genes revealed a hi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yap WH,Yeoh E,Tay A,Brenner S,Venkatesh B

    更新日期:2005-08-15 00:00:00

  • Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses.

    abstract::The timely and reliable processing of auditory and vestibular information within the inner ear requires highly sophisticated sensory transduction pathways. On a cellular level, these demands are met by hair cells, which respond to sound waves - or alterations in body positioning - by releasing glutamate-filled synapti...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Pangrsic T,Vogl C

    更新日期:2018-11-01 00:00:00

  • Structural insight into the interaction of ADP-ribose with the PARP WWE domains.

    abstract::The WWE domain is often identified in proteins associated with ubiquitination or poly-ADP-ribosylation. Structural information about WWE domains has been obtained for the ubiquitination-related proteins, such as Deltex and RNF146, but not yet for the poly-ADP-ribose polymerases (PARPs). Here we determined the solution...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: He F,Tsuda K,Takahashi M,Kuwasako K,Terada T,Shirouzu M,Watanabe S,Kigawa T,Kobayashi N,Güntert P,Yokoyama S,Muto Y

    更新日期:2012-11-02 00:00:00

  • Functional diversity along the transverse axis of hippocampal area CA1.

    abstract::Decades of neuroscience research have shed light on the hippocampus as a key structure for the formation of episodic memory. The hippocampus is divided into distinct subfields - CA1, CA2 and CA3. While accumulating evidence points to cellular and synaptic heterogeneity within each subfield, this heterogeneity has not ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Igarashi KM,Ito HT,Moser EI,Moser MB

    更新日期:2014-08-01 00:00:00

  • 12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin.

    abstract::The X-ray structure of bovine beta-lactoglobulin with the ligand 12-bromododecanoic acid as a model for fatty acids has been determined at a resolution of 2.23 A in the trigonal lattice Z form. The ligand binds inside the calyx, resolving a long-standing controversy as to where fatty-acid like ligands bind. The carbox...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Qin BY,Creamer LK,Baker EN,Jameson GB

    更新日期:1998-11-06 00:00:00

  • Comparative binding properties of linear and cyclic delta-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin.

    abstract::The range of delta-selectivity of linear and cyclic analogues of enkephalin in rat brain was found to be: [D-Pen2, L-Pen5] enkephalin (DPLPE) greater than [D-Pen2, D-Pen5] enkephalin (DPDPE) greater than [D-Thr2, Leu5] enkephalyl-Thr6 (DTLET) greater than [D-Ser2, Leu5] enkephalyl-Thr6 (DSLET). Saturation experiments ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Delay-Goyet P,Zajac JM,Rigaudy P,Foucaud B,Roques BP

    更新日期:1985-04-22 00:00:00

  • Selection for TRAIL resistance results in melanoma cells with high proliferative potential.

    abstract::To better understand the outcome of the interaction between TNF-related apoptosis-inducing factor (TRAIL) and tumor cells, we studied TRAIL-resistant melanoma cells resulting from prolonged exposure to TRAIL and found that they had higher proliferative activity than the parental cells both in vitro and in vivo. This w...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wu JJ,Zhang XD,Gillespie S,Hersey P

    更新日期:2005-03-28 00:00:00

  • Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.

    abstract::The structures of the M110 and M21 regulatory subunits of protein phosphatase-1M, the major enzyme which dephosphorylates myosin in smooth muscle, have been deduced from cloned cDNAs. The N-terminus of the M110 subunit from rat aorta contains seven ankyrin repeats, while the C-terminus of the M21 subunit from chicken ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chen YH,Chen MX,Alessi DR,Campbell DG,Shanahan C,Cohen P,Cohen PT

    更新日期:1994-12-12 00:00:00

  • Structural analysis of a new GC-specific insertion element IS186.

    abstract::A new insertion sequence, IS186, has been identified from Escherichia coli and sequenced. It contains 1336 base pairs with a terminal inverted repeat of 22 nucleotides. A long open reading frame, from an ATG codon at position 55 to a TAG termination codon at 1327, could code for a polypeptide of 424 amino acids. This ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chong P,Hui I,Loo T,Gillam S

    更新日期:1985-11-11 00:00:00

  • The role of Asp-295 in the catalytic mechanism of Leuconostoc mesenteroides sucrose phosphorylase probed with site-directed mutagenesis.

    abstract::Replacements of Asp-295 by Asn (D295N) and Glu (D295E) decreased the catalytic center activity of Leuconostoc mesenteroides sucrose phosphorylase to about 0.01% of the wild-type level (k(cat)=200s(-1)). Glucosylation and deglucosylation steps of D295N were affected uniformly, approximately 10(4.3)-fold, and independen...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mueller M,Nidetzky B

    更新日期:2007-04-03 00:00:00

  • Revisiting the odorant-binding protein LUSH of Drosophila melanogaster: evidence for odour recognition and discrimination.

    abstract::LUSH is a soluble odorant-binding protein of the fruit fly Drosophila melanogaster. Mutants not expressing this protein have been reported to lack the avoidance behaviour, exhibited by wild type flies, to high concentrations of ethanol. Very recently, the three-dimensional structure of LUSH complexed with short-chain ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhou JJ,Zhang GA,Huang W,Birkett MA,Field LM,Pickett JA,Pelosi P

    更新日期:2004-01-30 00:00:00

  • A sensitive and specific radioimmunoassay for leukotriene C4.

    abstract::A sensitive and specific radioimmunoassay suitable for direct measurement of leukotriene C4 was developed. Acetylated leukotriene C4 was coupled to polyamino bovine serum albumin using 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride as coupling agent. The conjugate in complete or incomplete Freund's adju...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Lindgren JA,Hammarström S,Goetzl EJ

    更新日期:1983-02-07 00:00:00

  • The expression of the embryonic gene Cripto-1 is regulated by OCT4 in human embryonal carcinoma NCCIT cells.

    abstract::Cripto-1 and OCT4, expressed in stem cells and cancers, play important roles in tumorigenesis. Here, we demonstrate that Cripto-1 expression is regulated by OCT4 in human embryonic carcinoma NCCIT cells. The endogenous expression of Cripto-1 and OCT4 is significantly reduced during differentiation. Cripto-1 expression...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Park SW,Do HJ,Han MH,Choi W,Kim JH

    更新日期:2018-01-01 00:00:00

  • Focal adhesion kinase and Src mediate integrin regulation of insulin receptor phosphorylation.

    abstract::We show here that phosphorylation of the insulin receptor and insulin receptor substrate-1 is increased when suspended cells are replated on fibronectin. This is not due to decreased numbers of cell surface receptors, alteration of insulin binding, or stimulation of a phosphatase activity in non-adherent cells. Expres...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: El Annabi S,Gautier N,Baron V

    更新日期:2001-11-02 00:00:00

  • Analysis of the black-eyed pea trypsin and chymotrypsin inhibitor-alpha-chymotrypsin complex.

    abstract::The black-eyed pea trypsin and chymotrypsin inhibitor (BTCI) is a member of the Bowman-Birk protease inhibitor (BBI) family. The three-dimensional model of the BTCI-chymotrypsin complex was built based on the homology to Bowman-Birk inhibitors with known structures. An extensive theoretical and experimental study of t...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: de Freitas SM,de Mello LV,da Silva MC,Vriend G,Neshich G,Ventura MM

    更新日期:1997-06-09 00:00:00

  • Empirical free energy as a target function in docking and design: application to HIV-1 protease inhibitors.

    abstract::Structure-based drug design requires the development of efficient computer programs for exploring the structural compatibility of various flexible ligands with a given receptor. While various algorithms are available for finding docked conformations, selecting a target function that can reliably score the conformation...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: King BL,Vajda S,DeLisi C

    更新日期:1996-04-08 00:00:00

  • Role of RIP140 in metabolic tissues: connections to disease.

    abstract::The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse processes as muscle...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: White R,Morganstein D,Christian M,Seth A,Herzog B,Parker MG

    更新日期:2008-01-09 00:00:00

  • Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae.

    abstract::The NAD-dependent glycerol-3-phosphate dehydrogenase (glycerol-3-phosphate:NAD+ oxidoreductase; EC; G3P DHG) was purified 178-fold to homogeneity from Saccharomyces cerevisiae strain H44-3D by affinity- and ion-exchange chromatography. SDS-PAGE indicated that the enzyme had a molecular mass of approximately 42...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Albertyn J,van Tonder A,Prior BA

    更新日期:1992-08-17 00:00:00

  • Metaphase chromosomes from mammalian cells stimulate fusion of artificial phospholipid vesicles.

    abstract::Isolated mitotic chromosomes are able to form complexes with phosphatidylcholine liposomes in the presence and absence of Ca2+ ions, in the latter case in the presence of polyamines. Interactions with chromosomes stimulates liposome fusion. The fusion is promoted by condensed and EDTA-decondensed chromosomes. ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Balakireva LA,Belyaev ND,Budker VG,Kiseleva EV

    更新日期:1991-06-24 00:00:00

  • Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi.

    abstract::The gene for titin, a 4MDa myofibrillar protein, was analysed in golden hamster DNAs from different sources, using human cDNA probes and PCR. In the DNA from the BHK-21-Bi subline of baby hamster kidney cells, extended sequences coding for Z-line associated domains were missing, indicating a deletion that renders titi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Jäckel M,Witt C,Antonova O,Curdt I,Labeit S,Jockusch H

    更新日期:1997-05-12 00:00:00

  • Mitochondrial potassium channels and reactive oxygen species.

    abstract::Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen spec...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Malinska D,Mirandola SR,Kunz WS

    更新日期:2010-05-17 00:00:00

  • Monovalent carboxylic ionophores inhibit transport of carbamoyl-phosphate synthetase I into mitochondria in Reuber hepatoma H-35 cells and cause accumulation of enzyme precursor.

    abstract::Transport of the precursor for carbamoyl-phosphate synthetase I into mitochondria in Reuber hepatoma H-35 cells was inhibited by adding monensin or nigericin to the culture medium at a concentration of 0.5 microM, and the enzyme precursor accumulated, mainly in the cytosolic fraction. Accumulated precursor was degrade...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kitagawa Y,Murakami A,Sugimoto E

    更新日期:1984-01-02 00:00:00

  • Vitronectin-dependent invasion of epithelial cells by Neisseria gonorrhoeae involves alpha(v) integrin receptors.

    abstract::Binding of vitronectin (VN) to Neisseria gonorrhoeae expressing the heparan sulfate proteoglycan (HSPG) specific Opa50 protein was recently shown to trigger bacterial internalization into distinct epithelial cell lines. We have investigated the role of VN-binding integrin receptors and protein kinase C (PKC) in VN-tri...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dehio M,Gómez-Duarte OG,Dehio C,Meyer TF

    更新日期:1998-03-06 00:00:00

  • Interleukin-2-dependent regulation of Na/K pump in human lymphocytes.

    abstract::The present study provides the first evidence that the abundance of catalytic alpha1-subunit of Na,K-ATPase increases in the course of T cell blast transformation. Immunodepressant cyclosporin A at anti-proliferative doses diminished the induction of alpha1 protein in activated lymphocytes. Furthermore, in competent T...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Marakhova I,Karitskaya I,Aksenov N,Zenin V,Vinogradova T

    更新日期:2005-05-23 00:00:00

  • Molecular mechanism of molt-inhibiting hormone (MIH) induced suppression of ecdysteroidogenesis in the Y-organ of mud crab: Scylla serrata.

    abstract::The present study was focused on the regulation of ecdysteroidogenesis in the Y-organ of Scylla serrata during molting cycle. A strong expression of molt-inhibiting hormone (MIH) and phosphorylation of ERK was predominantly observed in the postmolt and intermolt stages of Y-organs, whereas protein kinase C, steroidoge...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Imayavaramban L,Dhayaparan D,Devaraj H

    更新日期:2007-11-13 00:00:00

  • The induction of early response genes in rat smooth muscle cells by PDGF-AA is not sufficient to stimulate DNA-synthesis.

    abstract::The effect of the three platelet-derived growth factor (PDGF) isoforms AA, AB and BB on the induction of the early growth response genes c-fos, egr-1 and c-myc mRNA in vascular smooth muscle cells from rat was compared with their respective mitogenic potency. The three PDGF isoforms strongly stimulated the induction t...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sachinidis A,Schulte K,Ko Y,Meyer zu Brickwedde MK,Hoppe V,Hoppe J,Vetter H

    更新日期:1993-03-22 00:00:00

  • Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel.

    abstract::The primary structure of a novel subunit of the mouse NMDA (N-methyl-D-aspartate) receptor channel, designated epsilon 4, has been revealed by cloning and sequencing the cDNA. The epsilon 4 subunit shares high amino acid sequence identity with the epsilon 1, epsilon 2 and epsilon 3 subunits of the mouse NMDA receptor ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ikeda K,Nagasawa M,Mori H,Araki K,Sakimura K,Watanabe M,Inoue Y,Mishina M

    更新日期:1992-11-16 00:00:00

  • Prorenin processing by cathepsin B in vitro and in transfected cells.

    abstract::Renin, which catalyzes the initial proteolytic cleavage reaction in the production of angiotensins, is first synthesized as a zymogen, prorenin, and requires the proteolytic removal of an amino-terminal prosegment for activation in vivo. The lysosomal hydrolase cathepsin B has been proposed as a prorenin processing en...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Jutras I,Reudelhuber TL

    更新日期:1999-01-22 00:00:00