Abstract:
:Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Chavele KM,Ehrenstein MRdoi
10.1016/j.febslet.2011.07.043subject
Has Abstractpub_date
2011-12-01 00:00:00pages
3603-10issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00572-2journal_volume
585pub_type
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