Abstract:
:Glycogen storage disease type Ia (GSD-Ia) patients manifest a pro-atherogenic lipid profile but are not at elevated risk for developing atherosclerosis. Serum phospholipid, which correlates positively with the scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux, and apolipoprotein A-IV and E, acceptors for ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol transport, are increased in GSD-Ia mice. Importantly, sera from GSD-Ia mice are more efficient than sera from control littermates in promoting SR-BI- and ABCA1-mediated cholesterol effluxes. As the first step in reverse cholesterol transport, essential for cholesterol homeostasis, these observations provide one explanation why GSD-Ia patients are apparently protected against premature atherosclerosis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nguyen AD,Pan CJ,Shieh JJ,Chou JYdoi
10.1016/j.febslet.2005.07.042keywords:
subject
Has Abstractpub_date
2005-08-29 00:00:00pages
4713-8issue
21eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00904-Xjournal_volume
579pub_type
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