Abstract:
:Cytosolic extracts of trout and turkey erythrocytes were tested for their immunoreactivity with polyclonal and monoclonal antibodies to retinal arrestin (S-antigen), a cytosolic protein of photoreceptor cells involved in the desensitization of rhodopsin. After adsorption or immunoaffinity chromatography of the extracts, these antibodies specifically recognized a protein having a molecular weight similar to that of retinal arrestin. Because the G-protein-mediated transduction systems, such as visual and beta-adrenergic systems, display a high degree of structural and functional homology, the presence of arrestin-like proteins in non-photosensitive cells suggests that these proteins are involved in the transduction of chemical signals, with a possible role in receptor desensitization.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mirshahi M,Borgese F,Razaghi A,Scheuring U,Garcia-Romeu F,Faure JP,Motais Rdoi
10.1016/0014-5793(89)81663-1subject
Has Abstractpub_date
1989-12-04 00:00:00pages
240-3issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)81663-1journal_volume
258pub_type
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