Posttranscriptional regulation of c-myc RNA during early development of Xenopus laevis.

abstract：:The solution structure of endothelin-1, a newly discovered potent bicyclic peptide vaso-constrictor agent, has been investigated using 1H NMR conformational constraints and distance geometry calculations. The conformation is constrained by two disulphide bridges between Cys1-Cys15 and Cys3-Cys11 but the NMR data and c...

journal_title：FEBS letters

authors： Munro S,Craik D,McConville C,Hall J,Searle M,Bicknell W,Scanlon D,Chandler C

更新日期：1991-01-14 00:00:00

abstract：:Platinum electrodes can be coated with cytochrome b5-phospholipid monolayers by the Langmuir-Blodgett technique. Cyclic voltammetry of a series of dyes shows that the coated electrodes become selective for certain electroactive species. The electron transfer reactions of negatively charged species are inhibited at the...

journal_title：FEBS letters

authors： Zaba BN,Wilkinson MC,Taylor DM,Lewis TJ,Laidman DL

更新日期：1987-03-09 00:00:00

abstract：:A cDNA coding for a new subunit of soluble guanylyl cyclase with a calculated molecular mass of 81.7 kDa was cloned and sequenced. On the basis of sequence homology, the new subunit appears to be an isoform of the alpha 1-subunit and was designated alpha 2 as the new subunit is very similar to the alpha 1-subunit in t...

journal_title：FEBS letters

authors： Harteneck C,Wedel B,Koesling D,Malkewitz J,Böhme E,Schultz G

更新日期：1991-11-04 00:00:00

abstract：:Adhesion of platelets to the exposed extracellular matrix proteins at sites of vascular injury is partly regulated by the local fluid shear stress. Because the Leu33Pro (Pl(A)) polymorphism of integrin beta(3) confers only a modest increase in adhesion under static conditions, we used CHO and 293 cells expressing the ...

journal_title：FEBS letters

authors： Vijayan KV,Huang TC,Liu Y,Bernardo A,Dong JF,Goldschmidt-Clermont PJ,Alevriadou BR,Bray PF

更新日期：2003-04-10 00:00:00

abstract：:DNA complementary to the rat hypothalamic mRNA coding for the corticotropin-releasing factor precursor (prepro-CRF) has been cloned by screening a cDNA library with a human genomic DNA probe. Nucleotide sequence analysis of the cloned cDNA has revealed that rat prepro-CRF consists of 187 amino acid residues including ...

journal_title：FEBS letters

authors： Jingami H,Mizuno N,Takahashi H,Shibahara S,Furutani Y,Imura H,Numa S

更新日期：1985-10-21 00:00:00

abstract：:Differentiation enhancing factor (DEF) is a 29 kDa protein expressed in murine erythroleukemia (MEL) cells and active in promoting a significant increase in the rate of hexamethylenebisacetamide induced differentiation of these cells. The factor was recently shown to possess an amino acid sequence identical to that re...

journal_title：FEBS letters

authors： Melloni E,Sparatore B,Patrone M,Pessino A,Passalacqua M,Pontremoli S

更新日期：1995-07-24 00:00:00

abstract：:We have characterized the glucose transport system in the Kc cells of Drosophila melanogaster. The transporter is stereospecific and can be inhibited by both cytochalasin B and phloretin, with ki values of 4 microM and 30 microM for cytochalasin B and phloretin, respectively. Moreover, phlordzin does not affect uptake...

journal_title：FEBS letters

authors： Wang M,Wang C

更新日期：1993-02-15 00:00:00

abstract：:The effect of oxLDL on CD36 expression has been assessed in preadipocytes induced to differentiate. Novel evidence is provided that oxLDL induce a peroxisome proliferator-activated receptor gamma-independent CD36 overexpression, by up-regulating nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2). The nuclear t...

journal_title：FEBS letters

authors： D'Archivio M,Scazzocchio B,Filesi C,Varì R,Maggiorella MT,Sernicola L,Santangelo C,Giovannini C,Masella R

更新日期：2008-06-25 00:00:00

abstract：:Sulfate assimilation pathway is highly responsive to changes in environment, but the mechanisms of such regulation are only slowly beginning to unravel. Here we show evidence that PHYTOCHROME AND FLOWERING TIME 1 (PFT1) may be another component of the sulfate assimilation regulatory circuit. Transcriptional regulation...

journal_title：FEBS letters

authors： Koprivova A,Calderwood A,Lee BR,Kopriva S

更新日期：2014-04-02 00:00:00

abstract：:The oxidation of free methionine to methionine sulfoxide by chemically or enzymatically generated oxygen free radicals is presented. The physiological significance of this process in living cells is suggested. ...

journal_title：FEBS letters

authors： Scislowski PW,Davis EJ

更新日期：1987-11-16 00:00:00

abstract：:A synthetic peptide, KKKKRFSFKKSFKLSGFSFKK, containing the phosphorylation sites of the acidic 80-87 kDa protein kinase C substrate was used to identify phosphopeptides in enzyme digests of this protein from mouse fibroblast C3H/10T1/2 cells. Stimulation of phosphorylation occurred, in vivo, with TPA at Ser7, Ser11 an...

journal_title：FEBS letters

authors： Amess B,Manjarrez-Hernandez HA,Howell SA,Learmonth M,Aitken A

更新日期：1992-02-10 00:00:00

abstract：:Retinoic acid receptor-related orphan receptor-alpha (RORalpha) is a nuclear orphan receptor. Adenovirus-mediated overexpression of RORalpha1 and RORalpha4 suppressed tumor necrosis factor-alpha (TNF-alpha)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) ...

journal_title：FEBS letters

authors： Migita H,Satozawa N,Lin JH,Morser J,Kawai K

更新日期：2004-01-16 00:00:00

abstract：:A hybrid protein from Neisseria meningitidis, which contains both a peroxiredoxin and a glutaredoxin domain, has been isolated. The enzyme was active in the reduction of various peroxides and dehydroascorbate in the presence of reduced glutathione. These findings suggest that both the peroxiredoxin and glutaredoxin do...

journal_title：FEBS letters

authors： Rouhier N,Jacquot JP

更新日期：2003-11-06 00:00:00

abstract：:We previously identified and purified a nucleolar phosphoprotein, nucleophosmin/B23, as a stimulatory factor for replication from the adenovirus chromatin. We show here that nucleophosmin/B23 functions as a histone chaperone protein such as nucleoplasmin, TAF-I, and NAP-I. Nucleophosmin/B23 was shown to bind to histon...

journal_title：FEBS letters

authors： Okuwaki M,Matsumoto K,Tsujimoto M,Nagata K

更新日期：2001-10-12 00:00:00

abstract：:Prefibrillar cytotoxicity was suggested as a common amyloid characteristic. We showed two types of albebetin prefibrillar oligomers are formed during incubation at pH 7.3. Initial round-shaped oligomers consist of 10-15 molecules determined by atomic force microscopy, do not bind thioflavin-T and do not affect viabili...

journal_title：FEBS letters

authors： Zamotin V,Gharibyan A,Gibanova NV,Lavrikova MA,Dolgikh DA,Kirpichnikov MP,Kostanyan IA,Morozova-Roche LA

更新日期：2006-05-01 00:00:00

abstract：:In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests that oxidative stress inhibits this canonical Ire1 signalling pathway, activating instead an antioxidant stress response. We sought to d...

journal_title：FEBS letters

authors： Guerra-Moreno A,Ang J,Welsch H,Jochem M,Hanna J

更新日期：2019-05-01 00:00:00

abstract：:Ribosomal protection proteins (RPPs) confer bacterial resistance to tetracycline by releasing this antibiotic from ribosomes stalled in protein synthesis. RPPs share structural similarity to elongation factor G (EF-G), which promotes ribosomal translocation during normal protein synthesis. We constructed and functiona...

journal_title：FEBS letters

authors： Thakor NS,Nechifor R,Scott PG,Keelan M,Taylor DE,Wilson KS

更新日期：2008-04-16 00:00:00

abstract：:It is known that narcotic antagonists interact with many cholinergic pathways but less in known about specific mechanisms. Using neonatal rat myoballs to study single channel behaviour of the acetylcholinegated nicotinic receptor, it was found that micromolar concentrations of naltrexone had no effect on channel condu...

journal_title：FEBS letters

authors： Madsen BW,Albuquerque EX

更新日期：1985-03-11 00:00:00

abstract：:The SEC10 gene product is a member of the Exocyst complex essential for exocytosis in the budding yeast Saccharomyces cerevisiae. We report here the cloning and characterization of human Sec10p (hSec10p; GenBank accession number U85946). hSec10p is a 77-kDa protein with 23% amino acid identity to yeast Sec10p and 37% ...

journal_title：FEBS letters

authors： Guo W,Roth D,Gatti E,De Camilli P,Novick P

更新日期：1997-03-10 00:00:00

abstract：:Keratins form an intracellular keratin filament network in keratinocytes. Point mutations in the epidermal keratins could lead to the disruption of keratin filament formation, developing skin diseases such as epidermolytic hereditary palmoplantar keratoderma (EHPPK). We found a G to A transition in keratin 9 (K9) cDNA...

journal_title：FEBS letters

authors： Kobayashi S,Tanaka T,Matsuyoshi N,Imamura S

更新日期：1996-05-20 00:00:00

abstract：:As yet, the physiological significance of hydroxylation of anandamide and linoleoyl amides is unknown. Therefore, we investigated whether hydroxylation of ODNHEtOH and ODNH2 influences their binding abilities to the CB-1 receptor and whether it alters their reactivity towards a fatty acid amide hydrolase (FAAH) from r...

journal_title：FEBS letters

authors： van der Stelt M,Paoletti AM,Maccarrone M,Nieuwenhuizen WF,Bagetta G,Veldink GA,Finazzi Agrò A,Vliegenthart JF

更新日期：1997-10-06 00:00:00

abstract：:The serine peptidases, thrombocytin and PA-BJ, isolated from the venom of Bothrops atrox and Bothrops jararaca, respectively, induce platelet aggregation and granule secretion without clotting fibrinogen. The specific platelet aggregation activity of each enzyme was about 15 times lower than that of thrombin. This act...

journal_title：FEBS letters

authors： Santos BF,Serrano SM,Kuliopulos A,Niewiarowski S

更新日期：2000-07-21 00:00:00

abstract：:A conformational transition between E2 and E1 forms of Na, K-ATPase induced by different nucleotides has been studied under steady state conditions using the enzyme labelled with 5-iodoacetamidofluorescein. In the presence of K+ the plot of fluorescence as a function of [ATP], [ADP] or [CTP] (in a range of 5 microM-12...

journal_title：FEBS letters

authors： Lopina OD,Pindel EV,Boldyrev AA

更新日期：1990-06-18 00:00:00

abstract：:We have investigated the activity of STAT family members throughout a mammary developmental cycle. Transcripts for Stat 5 were upregulated during pregnancy whilst STAT1 and STAT3 mRNAs were expressed at constant levels. DNA binding complexes containing both STAT5a and 5b showed differing affinities for two naturally o...

journal_title：FEBS letters

authors： Philp JA,Burdon TG,Watson CJ

更新日期：1996-10-28 00:00:00

abstract：:We have recently cloned a cDNA encoding sucrose:fructan 6-fructosyltransferase (6-SFT), a key enzyme of fructan synthesis forming the beta-2,6 linkages typical of the grass fructans, graminans and phleins [Sprenger et al. (1995) Proc. Natl. Acad. Sci. USA 92, 11652-11656]. Here we report functional expression of 6-SFT...

journal_title：FEBS letters

authors： Sprenger N,Schellenbaum L,van Dun K,Boller T,Wiemken A

更新日期：1997-01-06 00:00:00

abstract：:In the methylerythritol phosphate pathway for isoprenoid biosynthesis, the GcpE/IspG enzyme catalyzes the conversion of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate into (E)-4-hydroxy-3-methylbut-2-enyl diphosphate. This reaction requires a double one-electron transfer involving a [4Fe-4S] cluster. A thylakoid prepara...

journal_title：FEBS letters

authors： Seemann M,Tse Sum Bui B,Wolff M,Miginiac-Maslow M,Rohmer M

更新日期：2006-03-06 00:00:00

abstract：:The guanine nucleotide exchange reaction catalyzed by elongation factor Ts is proposed to arise from the intrusion of the side chains of D80 and F81 near the Mg2+ binding site in EF-Tu. D80A and F81A mutants of E. coli EF-Ts were 2-3-fold less active in promoting GDP exchange with E. coli EF-Tu while the D80AF81A muta...

journal_title：FEBS letters

authors： Zhang Y,Li X,Spremulli LL

更新日期：1996-08-12 00:00:00

abstract：:Matrix metalloproteinase-13 (MMP-13) plays a critical role in parathyroid hormone (PTH)-induced bone resorption. PTH acts via protein kinase A (PKA) to phosphorylate and stimulate the transactivation of Runx2 for MMP-13 promoter activation. We show here that PTH stimulated Runx2 phosphorylation in rat osteoblastic cel...

journal_title：FEBS letters

authors： Selvamurugan N,Shimizu E,Lee M,Liu T,Li H,Partridge NC

更新日期：2009-04-02 00:00:00

abstract：:The family of lipases (triacylglycerol-acyl-hydrolases EC 3.1.1.3) constitutes an interesting class of enzymes because of their ability to interact with lipid-water interfaces, their wide range of substrate specificities, and their potential industrial applications. Here we report the first crystal structure of a bact...

journal_title：FEBS letters

authors： Noble ME,Cleasby A,Johnson LN,Egmond MR,Frenken LG

更新日期：1993-09-27 00:00:00

abstract：:A 4.8 kb DNA-fragment was cloned and sequenced encompassing the structural gene of PFL-deactivase (2.7 kb) and 2 kb of the 5' flanking region that contains the elements for anaerobic induction. A mutant lacking deactivase was shown to require exogenous electron acceptors for anaerobic growth with glucose. This reveale...

journal_title：FEBS letters

authors： Kessler D,Leibrecht I,Knappe J

更新日期：1991-04-09 00:00:00