Abstract:
:We have investigated the activity of STAT family members throughout a mammary developmental cycle. Transcripts for Stat 5 were upregulated during pregnancy whilst STAT1 and STAT3 mRNAs were expressed at constant levels. DNA binding complexes containing both STAT5a and 5b showed differing affinities for two naturally occurring STAT5 binding sites. In the involuting mammary gland STAT5 activity decreased whereas STAT3 was specifically activated. These observations reveal a complex pattern of activation of STAT factors during mammary growth, differentiation and remodelling and provide the first evidence for the involvement of STAT3 in development of the mammary gland.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Philp JA,Burdon TG,Watson CJdoi
10.1016/0014-5793(96)01069-1subject
Has Abstractpub_date
1996-10-28 00:00:00pages
77-80issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(96)01069-1journal_volume
396pub_type
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