Abstract:
:The solution structure of endothelin-1, a newly discovered potent bicyclic peptide vaso-constrictor agent, has been investigated using 1H NMR conformational constraints and distance geometry calculations. The conformation is constrained by two disulphide bridges between Cys1-Cys15 and Cys3-Cys11 but the NMR data and computed conformers show additional helical structure between residues Leu6 and Cys11. Our results are compared with previous conflicting reports on the solution conformation of this peptide.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Munro S,Craik D,McConville C,Hall J,Searle M,Bicknell W,Scanlon D,Chandler Cdoi
10.1016/0014-5793(91)80071-asubject
Has Abstractpub_date
1991-01-14 00:00:00pages
9-13issue
1eissn
0014-5793issn
1873-3468journal_volume
278pub_type
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