Abstract:
:Plasminogen activation is regulated by the interaction between urokinase-type plasminogen activator (uPA) and its specific glycolipid-anchored cell surface receptor (uPAR). uPAR is composed of three homologous domains and is the only multi-domain member of the Ly-6 family of glycolipid-anchored membrane proteins. Recent evidence has highlighted similarities between the individual domains of uPAR and the large family of secreted, single domain snake venom alpha-neurotoxins, suggesting that uPAR may adopt the same gross folding pattern as these structurally well characterized proteins. Structural aspects of the binding between alpha-neurotoxins and the acetylcholine receptor may have a major influence on future studies of the interaction between uPA and uPAR.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ploug M,Ellis Vdoi
10.1016/0014-5793(94)00674-1subject
Has Abstractpub_date
1994-08-01 00:00:00pages
163-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(94)00674-1journal_volume
349pub_type
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