Differential expression of AMPA glutamate receptor mRNAs in the rat adrenal gland.


:Localisation of mRNA encoding the four AMPA glutamate receptor subunits in the rat adrenal gland was investigated using in situ hybridisation. GluR1 is found in the zona glomerulosa of the cortex, GluR3 in the remaining parts of the cortex, GluR2 in adrenal medullary cells and GluR4 at a very low level in the zona glomerulosa. All four receptor mRNAs are found in medullary ganglion cells. The flip form of GluR2 and GluR3 dominate and the GluR2 mRNA is present in the arginine encoding form. Different cell populations of the adrenal gland may express homomeric forms of different receptor subtypes.




FEBS letters


Kristensen P




Has Abstract


1993-10-11 00:00:00














  • New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin.

    abstract::Silver and gold compounds were tested as potential inhibitors of aquaporins of plant- and human origin. Silver as AgNO(3) or silver sulfadiazine inhibited with high potency (EC(50) 1-10 microM) the water permeability of the peribacteroid membrane from soybean (containing Nodulin 26), the water permeability of plasma m...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Niemietz CM,Tyerman SD

    更新日期:2002-11-20 00:00:00

  • Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis.

    abstract::Fas/FasL interactions have been proposed as a potentially important mechanism mediating beta-cell death in type 1 diabetes. Recent investigations suggest RNA interference, afforded by small interfering RNAs (siRNA), can provide specific and robust gene silencing in mammalian cells. The current study attempted to inves...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Burkhardt BR,Lyle R,Qian K,Arnold AS,Cheng H,Atkinson MA,Zhang YC

    更新日期:2006-01-23 00:00:00

  • Increased basal gluconeogenesis in the aged rat.

    abstract::Post-absorptive gluconeogenesis from lactate measured in vivo increases 3-fold in 24-month-old rats compared to 3-month-old animals. Fractional lactate turnover rates showed no significant differences between the two groups of animals. Lower plasma glucose concentrations and insulin-glucagon ratios may explain the inc...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Satrústegui J,Cuezva JM,Machado A

    更新日期:1986-03-03 00:00:00

  • Adrenergic regulation of ureogenesis in hepatocytes from adrenalectomized rats. Possible involvement of two pathways of signal transduction in alpha 1-adrenergic action.

    abstract::In hepatocytes from control rats, the ureogenic action of epinephrine is mainly mediated through alpha 1-adrenoceptors and the effect is independent of the presence of extracellular calcium. In hepatocytes from adrenalectomized rats, both alpha 1- and beta-adrenoceptors are involved in the action of epinephrine. Furth...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hernández-Sotomayor SM,García-Sáinz JA

    更新日期:1984-01-30 00:00:00

  • Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells.

    abstract::The effect of dexamethasone on mRNA and protein synthesis of lipocortins (LCT) 1, 2 and 5 has been investigated in U-937 cells. A constitutive expression of both mRNAs and proteins was detected in undifferentiated U-937 cells. This constitutive level was increased time- and dose-dependently by incubation with phorbol ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Solito E,Raugei G,Melli M,Parente L

    更新日期:1991-10-21 00:00:00

  • FAK inhibitors induce cell multinucleation and dramatically increase pro-tumoral cytokine expression in RAW 264.7 macrophages.

    abstract::Macrophages are abundant in the tumor microenvironment. They are highly plastic and able to acquire pro-tumoral phenotypes in response to microenvironmental stimuli. When we treated RAW 264.7 macrophages with inhibitors of various oncogenic pathways, we found that the focal adhesion kinase (FAK) inhibitors PF573228 an...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: He X,Chen X,Li B,Ji J,Chen S

    更新日期:2017-12-01 00:00:00

  • Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils.

    abstract::Inflammation is highly regulated by various agents. Unexpectedly, we report here that the damage-associated molecular pattern S100A9 protein, a potent neutrophil activator and inducer of cytokine production in monocytes, is not a direct activator of cytokine production in human neutrophils. However, S100A9 primed IL-8...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Simard JC,Noël C,Tessier PA,Girard D

    更新日期:2014-06-13 00:00:00

  • The structure of procalcitonin of the salmon as deduced from its cDNA sequence.

    abstract::Oligonucleotide probes based on the known amino acid sequence of salmon calcitonin were used to screen a cDNA library obtained from ultimobranchial glands of salmon for clones encoding salmon calcitonin. From the cDNA sequence of strongly hybridizing clones the complete primary structure of the calcitonin precursor co...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Pöschl E,Lindley I,Hofer E,Seifert JM,Brunowsky W,Besemer J

    更新日期:1987-12-21 00:00:00

  • Light signals are transduced to the phosphorylation of 15 kDa proteins in Neurospora crassa.

    abstract::A microsomal fraction prepared from the mycelia of the band (bd) strain of Neurospora crassa showed enhanced phosphorylation of two small proteins with molecular masses of around 15 kDa (ps15) by the irradiation of the reaction mixture containing [gamma-32P]ATP at 0 degrees C for 1 s with blue light (450 nm, 6 mumol/m...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Oda K,Hasunuma K

    更新日期:1994-05-30 00:00:00

  • Stress-specific aggregation of proteins in the amyloid bodies.

    abstract::Physiological amyloid aggregation occurs within the nuclei of stress-treated cells. These structures, termed Amyloid bodies (A-bodies), assemble through the rapid accumulation of proteins into dense membrane-less organelles, which possess the same biophysical properties as plaques observed in many amyloid-based diseas...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Marijan D,Tse R,Elliott K,Chandhok S,Luo M,Lacroix E,Audas TE

    更新日期:2019-11-01 00:00:00

  • Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model.

    abstract::Rats bearing the Yoshida AH-130 ascites hepatoma showed an increased expression of both uncoupling protein-2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation. Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair-fed an...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sanchís D,Busquets S,Alvarez B,Ricquier D,López-Soriano FJ,Argilés JM

    更新日期:1998-10-09 00:00:00

  • Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins.

    abstract::Plasminogen activation is regulated by the interaction between urokinase-type plasminogen activator (uPA) and its specific glycolipid-anchored cell surface receptor (uPAR). uPAR is composed of three homologous domains and is the only multi-domain member of the Ly-6 family of glycolipid-anchored membrane proteins. Rece...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Ploug M,Ellis V

    更新日期:1994-08-01 00:00:00

  • Amiloride at pH 7.0 inhibits the Na(+)-driven flagellar motors of Vibrio alginolyticus but allows cell growth.

    abstract::Amiloride, a specific inhibitor for the Na(+)-driven flagellar motors of alkalophilic Bacillus, is known to inhibit secondarily the growth of alkalophiles. The motility of a marine Vibrio, V. alginolyticus, was almost completely inhibited by 2 mM amiloride either at pH 7.0 or 8.5. We found that this concentration of a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Atsumi T,Maekawa Y,Tokuda H,Imae Y

    更新日期:1992-12-14 00:00:00

  • Evidence for two H2O2-binding sites in ferric cytochrome c oxidase. Indication to the O-cycle?

    abstract::H2O2 addition to the oxidized cytochrome c oxidase reconstituted in liposomes brings about a red shift of the Soret band of the enzyme and an increased absorption in the visible region with two distinct peaks at approximately 570 and 605 nm. Throughout pH range 6-8.5, the spectral changes at 570 nm and in the Soret ba...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Vygodina T,Konstantinov AA

    更新日期:1987-07-27 00:00:00

  • A 5 S rRNA-like secondary structure in the 7 SL RNA may define a ribosomal binding site of the signal recognition particle.

    abstract::A new secondary structure model for parts of the 7 SL RNA is proposed which indicates for a stretch of at least 40 bases a strong structural homology to the ribosomal protein L5 binding site of eukaryotic 5 S rRNA. It is suggested that the 5 S rRNA-like structural part of 7 SL RNA mediates binding of the signal recogn...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Boehm S

    更新日期:1987-02-09 00:00:00

  • Mechano-chemical effects of Ca(2+) in cross-linked troponin-C films.

    abstract::Changes in troponin C (TnC) conformation upon Ca(2+) binding forms the basis for regulatory and structural functions of TnC molecules. In the present study, Ca(2+)-induced conformational changes in TnC were observed by mechanical measurements. TnC films were prepared by drying or electrospraying TnC solutions, cross-l...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bukatina AE,Morozov VN,Gusev NB,Sieck GC

    更新日期:2002-07-31 00:00:00

  • Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding.

    abstract::The interaction of Bordetella pertussis adenylate cyclase toxin (CyaA) with complement receptor 3 (CR3, CD11b/CD18) involves N-linked oligosaccharide chains. To investigate the relative importance of the individual N-glycans of CR3 for toxin activity, the asparagine residues of the consensus N-glycosylation sites of C...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hasan S,Osickova A,Bumba L,Novák P,Sebo P,Osicka R

    更新日期:2015-01-30 00:00:00

  • Le couplage phosphore-phosphore dans l'adenosine di- et triphosphate.

    abstract::The pH dependence of spin-spin coupling constants J (P-O-P) of ADP and ATP has been determined from the phosphorus NMR spectra at 0 degrees. The variation curves have been interpreted as titration curves. These give different pK values. Comparison with the tripolyphosphate shows the existence of triphosphate chain str...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ellenberger M,Brehamet L,Villemin M,Toma F

    更新日期:1970-06-01 00:00:00

  • Calcium influx through annexin V ion channels into large unilamellar vesicles measured with fura-2.

    abstract::A new assay for the calcium channel activity of annexin V was developed. The calcium-sensitive fluorescence indicator, fura-2, was incorporated into large unilamellar vesicles (LUV). After establishing a calcium gradient across the liposomal membranes, native or mutated annexin V was added. The resulting calcium influ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Berendes R,Burger A,Voges D,Demange P,Huber R

    更新日期:1993-02-08 00:00:00

  • Prediction of the maximal stability temperature of monomeric globular proteins solely from amino acid sequence.

    abstract::Globular protein thermostability is characterized the cold denaturation, maximal stability (Tms) and heat denaturation temperatures. For mesophilic globular proteins, Tms typically ranges from -25 degrees C to +35 degrees C. We show that the indirect estimate of Tms from calorimetry and the direct estimate from chemic...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ganesh C,Eswar N,Srivastava S,Ramakrishnan C,Varadarajan R

    更新日期:1999-07-02 00:00:00

  • Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient.

    abstract::We analysed the biochemical properties of insulin receptors of a Type A insulin resistant patient with a single heterozygous point mutation substituting Gln for Arg1174. Insulin binding capacity and affinity to Epstein-Barr virus transformed lymphocytes was normal. Quantitative analysis of autophosphorylation and subs...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Moritz W,Froesch ER,Böni-Schnetzler M

    更新日期:1994-09-05 00:00:00

  • The inhibitory effect of nitrite, a stable product of nitric oxide (NO) formation, on arginase.

    abstract::Macrophages contain arginase and an inducible NO synthase, demonstrated by using L-arginine, the common substrate, for production of both nitric oxide and urea. Arginase was inhibited by nitrite, the stable end product of NO. This inhibition was non-competitive, and could not be explained by the reaction of nitrite wi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hrabák A,Bajor T,Temesi A,Mészáros G

    更新日期:1996-07-22 00:00:00

  • Nature of respiratory stimulation in hyperthyroidism: the redox behaviour of cytochrome c.

    abstract::Hyperthyroid mitochondria show an increased Km and Vmax in the high affinity phase of cytochrome oxidase kinetics. During inhibitor titrations, cytochrome c shows a different redox behaviour in hyperthyroid with respect to protonophore-treated euthyroid mitochondria. The observations are discussed in terms of a differ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Schmehl I,Luvisetto S,Canton M,Gennari F,Azzone GF

    更新日期:1995-11-20 00:00:00

  • Dosage compensation in flies: mechanism, models, mystery.

    abstract::Dosage compensation involves fine-tuning of gene expression at the level of entire chromosomes. The principles that assure selective targeting of the male X chromosome in Drosophila and the mechanism by which transcription levels are adjusted in a twofold range are still mysterious. We discuss the prevalent models in ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Straub T,Dahlsveen IK,Becker PB

    更新日期:2005-06-13 00:00:00

  • Purification of a 175-kDa membrane protein, its localization in smooth and cardiac muscles. Interaction with cytoskeletal protein - vinculin.

    abstract::A new 175-kDa membrane protein was isolated from chicken gizzard smooth muscle. Antibodies to 175-kDa protein were used for localization of this protein in smooth and cardiac muscles. In both types of muscle 175-kDa protein was localized near plasma membrane. 175-kDa protein was able to interact specifically with vinc...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Koteliansky VE,Gneushev GN,Belkin AM

    更新日期:1985-03-11 00:00:00

  • Reconstitution of proteasome activator PA28 from isolated subunits: optimal activity is associated with an alpha,beta-heteromultimer.

    abstract::PA28, a 200 kDa activator of 20S proteasomes, was purified from human placenta and was gel electrophoretically resolved into two different subunits, alpha and beta. In reconstitution experiments, alpha-subunits alone were found to re-associate forming homooligomers with an M(r) of about 200 kDa, which elicit a stimula...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kuehn L,Dahlmann B

    更新日期:1996-09-30 00:00:00

  • Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells.

    abstract::Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short-term experiments, insulin-like growth factor I (IGF I) stimulated the incorporation of [14C] glucose into glycogen. When IGF I w...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Schmid C,Steiner T,Froesch ER

    更新日期:1984-07-23 00:00:00

  • Addition of a methyl group changes both the catalytic velocity and thermostability of the neutral protease from Bacillus stearothermophilus.

    abstract::Specific activity was compared between wild-type (WT) neutral protease from Bacillus stearothermophilus and mutant protease (M1; Gly144 replaced by Ala144) with enhanced thermostability. When casein was used as a substrate, M1 showed 1.5-times higher specific activity than that of WT. In contrast, the specific activit...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Takagi M,Imanaka T

    更新日期:1989-08-28 00:00:00

  • Determination of fast proton exchange rates of biomolecules by NMR using water selective diffusion experiments.

    abstract::We present a new water selective pulse sequence allowing rapid determination of exchange rates of labile protons on the millisecond time scale. Using diffusion measurements, exchange rates of resolved protons can be determined without prior knowledge of relaxation parameters in a short overnight experiment. The use of...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Böckmann A,Guittet E

    更新日期:1997-11-24 00:00:00

  • Pro-urokinase and prekallikrein are both associated with platelets. Implications for the intrinsic pathway of fibrinolysis and for therapeutic thrombolysis.

    abstract::The contact-dependent intrinsic pathway of fibrinolysis involving factor XII, prekallikrein (PK) and pro-urokinase (pro-UK) remains poorly understood. Casein autography of washed, intact platelets revealed both PK and pro-UK. Accordingly, platelets may mediate physiological thrombolysis by this pathway since factor XI...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gurewich V,Johnstone M,Loza JP,Pannell R

    更新日期:1993-03-08 00:00:00