Abstract:
:The trend of the electric field and the value of the electric field flux, sensed by the superoxide substrate in the proximity of the active site, were found to be constant in three highly homologous Cu,Zn superoxide dismutases from ox, pig and sheep, which display large differences in net protein charge and distribution of electrically charged surface residues but very similar catalytic rate constants. The spatial relationship of charges on the protein surface apparently has been conserved during the evolution of this enzyme to create electrostatic facilitation of catalysis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Desideri A,Falconi M,Parisi V,Rotilio Gdoi
10.1016/0014-5793(89)80681-7subject
Has Abstractpub_date
1989-06-19 00:00:00pages
45-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(89)80681-7journal_volume
250pub_type
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