Pro-urokinase and prekallikrein are both associated with platelets. Implications for the intrinsic pathway of fibrinolysis and for therapeutic thrombolysis.

Abstract:

:The contact-dependent intrinsic pathway of fibrinolysis involving factor XII, prekallikrein (PK) and pro-urokinase (pro-UK) remains poorly understood. Casein autography of washed, intact platelets revealed both PK and pro-UK. Accordingly, platelets may mediate physiological thrombolysis by this pathway since factor XIIa activates PK and kallikrein activates pro-UK. Acid washing dissociated PK but not pro-UK from platelets. Exogenous pro-UK was specifically incorporated by platelets from the ambient fluid and similarly could not be dissociated from intact platelets. Therefore, platelets may also mediate an effect from therapeutically administered pro-UK by prolonging its half-life.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Gurewich V,Johnstone M,Loza JP,Pannell R

doi

10.1016/0014-5793(93)80537-5

subject

Has Abstract

pub_date

1993-03-08 00:00:00

pages

317-21

issue

3

eissn

0014-5793

issn

1873-3468

pii

0014-5793(93)80537-5

journal_volume

318

pub_type

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