Abstract:
:Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), a highly inducible transcriptional coactivator regulating energy homeostasis, is down-regulated in hepatoma tissues. To dissect its role in hepato-tumorigenesis, Ingenuity Pathway Analysis was applied to construct pathways affected by PGC-1alpha upregulation in HepG2 hepatoma cells based on our microarray data. Interestingly, migration of these cells was markedly diminished by PGC-1alpha overexpression in consistency with Ingenuity results. Moreover, a deduced expression increase of E-cadherin was also observed in PGC-1alpha-overexpressing HepG2 cells. Finally, transient transfection and chromatin-immunoprecipitation assays suggested that increased histone acetylation might be responsible for PGC-1alpha-mediated transactivation of a minimal E-cadherin promoter.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lee HJ,Su Y,Lui WY,Chau GY,Yin PH,Lee HC,Chi CWdoi
10.1016/j.febslet.2008.01.033subject
Has Abstractpub_date
2008-03-05 00:00:00pages
627-34issue
5eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00058-6journal_volume
582pub_type
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