Abstract:
:Originally identified as multicopy suppressor of a lethal growth arrest caused by expression of a tumour mutant cDNA of p53 in fission yeast the tms1 gene product was found to form stable complexes with p53 in yeast. By using purified recombinant proteins multimeric complexes of tms1 and p53 could be demonstrated and recently the p53 binding site on the tms1 protein was established to the sequence YYITTEDFCT (aa 116-125) in the vicinity of a well conserved cell division motif. Here we report the precise mapping of the tms1 binding site on the p53 protein to the sequence LQIRGRERFE (aa 330-339) which defines a new functional domain on the p53 protein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wagner P,Fuchs A,Prowald A,Montenarh M,Nastainczyk Wdoi
10.1016/0014-5793(95)01329-6subject
Has Abstractpub_date
1995-12-18 00:00:00pages
155-8issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(95)01329-6journal_volume
377pub_type
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