Abstract:
:Trefoil factor family (TFF)-domain peptides 1-3 are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wright NA,Hoffmann W,Otto WR,Rio MC,Thim Ldoi
10.1016/s0014-5793(97)00424-9subject
Has Abstractpub_date
1997-05-19 00:00:00pages
121-3issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00424-9journal_volume
408pub_type
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