Abstract:
:Recently, the existence and extended diversity of antimicrobial peptides has been revealed in two mussel species. These molecules are classified into four groups according to common features of their primary structure: defensins, mytilins, myticins and mytimycin. In Mytilus galloprovincialis, gene structure reveals synthesis as precursors in circulating hemocytes. Synthesised even in absence of challenge, the precursors mature and the peptides are stored in granules as active forms. The different peptides are engaged in the destruction of bacteria inside phagocytes, before being released into hemolymph to participate in systemic responses. Such involvement in anti-infectious responses is unique, and apparently more related to those of mammalian phagocytes than to those of insects.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mitta G,Vandenbulcke F,Roch Pdoi
10.1016/s0014-5793(00)02192-xkeywords:
subject
Has Abstractpub_date
2000-12-15 00:00:00pages
185-90issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)02192-Xjournal_volume
486pub_type
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