Abstract:
:A drastic inhibition of protein synthesis occurs in HeLa cells treated with human lymphoblastoid interferon and infected with poliovirus. At the time when this inhibition has been established no degradation of 32P-labelled ribosomal RNA can be detected. Isolation of the mRNAs from poliovirus-infected cells plus or minus interferon treatment, followed by translation in a reticulocyte lysate indicates that cellular mRNAs remain active. These results suggest that gross degradation of cellular RNA does not occur in interferon-treated poliovirus-infected HeLa cells and that a non-specific nuclease induced by 2'-5' A is not responsible for the inhibition of protein synthesis observed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Muñoz A,Harvey R,Carrasco Ldoi
10.1016/0014-5793(83)80942-9subject
Has Abstractpub_date
1983-08-22 00:00:00pages
87-92issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(83)80942-9journal_volume
160pub_type
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