Abstract:
:Folding of nascent chains resembles the decoding of spoken language in that information is emitted as a unidirectional, one-dimensional string of elements, with higher structures and long-distance interactions emerging with time. Applying a "pseudolinguistic' analysis of structure to a set of all 36 possible six-stranded antiparallel beta-sandwich topologies reveals new order principles and reduces the complexity of this family significantly. The simple connectivity diagrams ("linguistic trees') proposed here allow predictions of the speed and cooperativity of beta-sheet folding and help understanding the cotranslational folding from the N-terminus.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gross Mdoi
10.1016/0014-5793(96)00727-2subject
Has Abstractpub_date
1996-07-29 00:00:00pages
249-52issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(96)00727-2journal_volume
390pub_type
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