Abstract:
:In vitro cultured blood cells for transfusion purposes provide a safe alternative to donor blood, particularly for patients who require recurrent transfusions, and can be used as carriers of therapeutic molecules. In vitro derivation of hematopoietic cell types from human-induced pluripotent stem cells (iPSCs) allows for a constant, well-defined production pipeline for such advanced therapeutic and medicinal products. Application of selected iPSC-derived hematopoietic stem cells and hematopoietic effector cells in transplantation/transfusions would avoid the risk of alloimmunization and blood-borne diseases, as well as enable the production of enhanced blood cells expressing molecules that enforce blood cell function or endow novel therapeutic properties. Here, we discuss the state of the art approaches to produce erythroid, megakaryoid and myeloid cells from iPSCs and the biological and technical hurdles that we need to overcome prior to therapeutic application.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hansen M,von Lindern M,van den Akker E,Varga Edoi
10.1002/1873-3468.13599subject
Has Abstractpub_date
2019-12-01 00:00:00pages
3288-3303issue
23eissn
0014-5793issn
1873-3468journal_volume
593pub_type
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