Abstract:
:The binding of fibronectin and fibronectin fragments to the enterotoxigenic strain E. coli B34289c was studied. E. coli cells bound to two distinct sites of fibronectin, one being the N-terminal domain, which also contains the binding sites for staphylococci and streptococci, and the other located within the central heparin binding region. In addition, the N-terminal and the heparin binding domain mediated the attachment of bacteria in a solid phase binding assay. E. coli cells expressed two classes of receptors, the first, a 17 kDa protein, recognized by the N-terminal fragment and the second, having a mol. mass of 55 kDa, which interacts with the internal heparin binding domain. Bacterial receptors, which bind the N-terminal end of fibronectin, may be structurally related.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Visai L,Bozzini S,Petersen TE,Speciale L,Speziale Pdoi
10.1016/0014-5793(91)81238-4subject
Has Abstractpub_date
1991-09-23 00:00:00pages
111-4issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(91)81238-4journal_volume
290pub_type
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